About: Human Coronavirus in Hospitalized Children With Respiratory Tract Infections: A 9-Year Population-Based Study From Norway

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About: Human Coronavirus in Hospitalized Children With Respiratory Tract Infections: A 9-Year Population-Based Study From Norway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Coronavirus in Hospitalized Children With Respiratory Tract Infections: A 9-Year Population-Based Study From Norway
Creator	Christensen, Andreas Døllner, Henrik Krokstad, Sidsel Moe, Nina Nordbø, Svein Skanke, Lars Heimdal, Inger
Source	Medline; PMC
abstract	BACKGROUND: The burden of human coronavirus (HCoV)-associated respiratory tract infections (RTIs) in hospitalized children is poorly defined. We studied the occurrence and hospitalization rates of HCoV over 9 years. METHODS: Children from Sør-Trøndelag County, Norway, hospitalized with RTIs and asymptomatic controls, were prospectively enrolled from 2006 to 2015. Nasopharyngeal aspirates were analyzed with semiquantitative polymerase chain reaction (PCR) tests for HCoV subtypes OC43, 229E, NL63, and HKU1, and 13 other respiratory pathogens. RESULTS: HCoV was present in 9.1% (313/3458) of all RTI episodes: 46.6% OC43, 32.3% NL63, 16.0% HKU1, and 5.8% 229E. Hospitalization rates for HCoV-positive children with lower RTIs were 1.5 and 2.8 per 1000 <5 and <1 years of age, respectively. The detection rate among controls was 10.2% (38/373). Codetections occurred in 68.1% of the patients and 68.4% of the controls. In a logistic regression analysis, high HCoV genomic loads (cycle threshold <28 in PCR analysis) were associated with RTIs (odds ratio = 3.12, P = .016) adjusted for relevant factors. CONCLUSIONS: HCoVs occurred in 1 of 10 hospitalized children with RTIs and asymptomatic controls. A high HCoV genomic load was associated with RTI. HCoVs are associated with a substantial burden of RTIs in need of hospitalization.
has issue date	2019-04-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jiy646
bibo:pmid	30418633
has license	no-cc
sha1sum (hex)	7b718c2197a63bf718cebed2894fe47f7d90c6b6
schema:url	https://doi.org/10.1093/infdis/jiy646
resource representing a document's title	Human Coronavirus in Hospitalized Children With Respiratory Tract Infections: A 9-Year Population-Based Study From Norway
has PubMed Central identifier	PMC7107437
has PubMed identifier	30418633
schema:publication	J Infect Dis
resource representing a document's body	covid:7b718c2197a63bf718cebed2894fe47f7d90c6b6#body_text
is schema:about of	named entity 'Study' named entity 'RATES' named entity 'HOSPITALIZATION' named entity 'POORLY DEFINED' named entity 'YEARS' named entity 'HOSPITALIZED CHILDREN' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'HUMAN CORONAVIRUS' named entity 'POPULATION-BASED STUDY' named entity 'JOURNAL ' named entity 'YEAR' named entity 'INFECTIOUS DISEASES' named entity 'OCCURRENCE' named entity 'NORWAY' named entity 'HOSPITALIZED CHILDREN' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'BACKGROUND' named entity 'HUMAN CORONAVIRUS' named entity 'BURDEN' named entity 'ASSOCIATED' covid:arg/7b718c2197a63bf718cebed2894fe47f7d90c6b6 named entity 'interquartile range' named entity 'Norway' named entity 'Written consent' named entity 'NL63' named entity 'coronavirus' named entity 'Background' named entity 'Respiratory' named entity 'human coronavirus' named entity 'Human Coronavirus' named entity 'enterovirus' named entity 'odds ratios' named entity 'NL63' named entity 'HMPV' named entity 'viruses' named entity 'asthma exacerbation' named entity 'viruses' named entity '229E' named entity 'IBM SPSS Statistics' named entity 'NL63' named entity 'TaqMan' named entity 'incidence rates' named entity 'PCR' named entity 'NL63' named entity 'human parechovirus' named entity 'cytostatic' named entity 'medical records' named entity 'asymptomatic infections' named entity 'nucleic acids' named entity 'NL63' named entity 'acute laryngitis' named entity 'high-risk' named entity 'Human coronaviruses' named entity 'odds ratios' named entity '10.5' named entity 'control group' named entity 'OC43' named entity 'long-term' named entity 'NL63' named entity 'RSV' named entity '1.6' named entity 'HRV' named entity 'HKU1' named entity 'OC43' named entity 'pandemics' named entity 'logistic regression' named entity 'otitis media' named entity 'HKU1' named entity 'infection' named entity 'confounder' named entity 'RSV' named entity 'Mann-Whitney U test' named entity 'asymptomatic' named entity 'NL63' named entity 'respiratory tract infections'

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