About: Arenavirus Quasispecies and Their Biological Implications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Arenavirus Quasispecies and Their Biological Implications
Creator	Grande-Pérez, Ana De La Torre, Juan Martin, Á De La Torre, J Grande-Pérez, A Martin, Veronica Moreno, Hector Moreno, Á
source	Medline; PMC
abstract	The family Arenaviridae currently comprises over 20 viral species, each of them associated with a main rodent species as the natural reservoir and in one case possibly phyllostomid bats. Moreover, recent findings have documented a divergent group of arenaviruses in captive alethinophidian snakes. Human infections occur through mucosal exposure to aerosols or by direct contact of abraded skin with infectious materials. Arenaviruses merit interest both as highly tractable experimental model systems to study acute and persistent infections and as clinically important human pathogens including Lassa (LASV) and Junin (JUNV) viruses, the causative agents of Lassa and Argentine hemorrhagic fevers (AHFs), respectively, for which there are no FDA-licensed vaccines, and current therapy is limited to an off-label use of ribavirin (Rib) that has significant limitations. Arenaviruses are enveloped viruses with a bi-segmented negative strand (NS) RNA genome. Each genome segment, L (ca 7.3 kb) and S (ca 3.5 kb), uses an ambisense coding strategy to direct the synthesis of two polypeptides in opposite orientation, separated by a noncoding intergenic region (IGR). The S genomic RNA encodes the virus nucleoprotein (NP) and the precursor (GPC) of the virus surface glycoprotein that mediates virus receptor recognition and cell entry via endocytosis. The L genome RNA encodes the viral RNA-dependent RNA polymerase (RdRp, or L polymerase) and the small (ca 11 kDa) RING finger protein Z that has functions of a bona fide matrix protein including directing virus budding. Arenaviruses were thought to be relatively stable genetically with intra- and interspecies amino acid sequence identities of 90–95 % and 44–63 %, respectively. However, recent evidence has documented extensive arenavirus genetic variability in the field. Moreover, dramatic phenotypic differences have been documented among closely related LCMV isolates. These data provide strong evidence of viral quasispecies involvement in arenavirus adaptability and pathogenesis. Here, we will review several aspects of the molecular biology of arenaviruses, phylogeny and evolution, and quasispecies dynamics of arenavirus populations for a better understanding of arenavirus pathogenesis, as well as for the development of novel antiviral strategies to combat arenavirus infections.
has issue date	2015-10-16(xsd:dateTime)
bibo:doi	10.1007/82_2015_468
bibo:pmid	26472215
has license	no-cc
sha1sum (hex)	7b7d75592f76297286d31c1a5a2e9904a6f5c447
schema:url	https://doi.org/10.1007/82_2015_468
resource representing a document's title	Arenavirus Quasispecies and Their Biological Implications
has PubMed Central identifier	PMC7122398
has PubMed identifier	26472215
schema:publication	Quasispecies: From Theory to Experimental Systems
resource representing a document's body	covid:7b7d75592f76297286d31c1a5a2e9904a6f5c447#body_text
is schema:about of	named entity 'stable' named entity 'pathogens' named entity 'virus' named entity 'orientation' named entity 'agents' named entity 'current' named entity 'endocytosis' named entity 'polymerase' named entity 'RNA' named entity 'kDa' named entity 'However' named entity 'BIOLOGICAL' named entity 'DATA' named entity 'HIGHLY' named entity 'ISOLATES' named entity 'PRECURSOR' named entity 'CURRENTLY' named entity 'FINDINGS' named entity 'TO DIRECT' named entity 'CELL' named entity 'STABLE' named entity 'INCLUDING' named entity 'EXPERIMENTAL MODEL' named entity 'AEROSOLS' named entity 'FDA' named entity 'RESERVOIR' named entity 'LIMITATIONS' named entity 'SNAKES' named entity 'RODENT' named entity 'ORIENTATION' named entity 'LICENSED' named entity 'GENETIC VARIABILITY' named entity 'INFECTIOUS' named entity 'PROTEIN ' named entity 'ARENAVIRUSES' named entity 'VIRAL' named entity 'THEIR' named entity 'OFF-LABEL USE' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'HUMAN' named entity 'LIMITED' named entity 'DIRECT' named entity 'EVIDENCE' named entity 'RIBAVIRIN' named entity 'SEGMENTED ' named entity 'THESE' named entity 'ARENAVIRUS' named entity 'FAMILY' named entity 'MEDIATES' named entity 'GENOMIC' named entity 'PERSISTENT' named entity 'RELATED' named entity 'ARENAVIRIDAE' named entity 'SYNTHESIS' named entity 'EXPOSURE TO' named entity 'ACUTE' named entity 'CAUSATIVE AGENTS' named entity 'GROUP' named entity 'NATURAL' named entity '3.5' named entity 'SKIN' named entity 'ARENAVIRUS' named entity 'POLYPEPTIDES' named entity 'VACCINES' named entity 'PROVIDE' named entity 'ENTRY' named entity 'VIRUSES' named entity 'EVIDENCE OF' named entity 'INFECTIONS' named entity 'MUCOSAL' named entity 'STRONG' named entity 'IN THE FIELD' named entity 'HEMORRHAGIC FEVERS' named entity 'ASSOCIATED WITH'

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