About: Temporal-Spatial Analysis of Severe Acute Respiratory Syndrome among Hospital Inpatients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Temporal-Spatial Analysis of Severe Acute Respiratory Syndrome among Hospital Inpatients
Creator	Li, Yuguo Lee, Nelson Wong, Tze Chiu, Yuk Yu, Ignatius
source	Medline; PMC
abstract	Background. We report the temporal-spatial spread of severe acute respiratory syndrome (SARS) among inpatients in a hospital ward during a major nosocomial outbreak and discuss possible mechanisms for the outbreak. Methods. All inpatients who had stayed in the same ward as the initial index case patient for any duration before isolation were recruited into a cohort and followed up to document the occurrence of SARS. The normalized concentration of virus-laden aerosols at different locations of the ward was estimated by use of computational fluid dynamics modeling. The attack rates in the various subgroups stratified by bed location were calculated. Multivariate Cox proportional hazards regression was used to document important risk factors. Results. The overall attack rate of SARS was 41% (30 of 74 subjects). It was 65%, 52%, and 18% in the same bay, adjacent bay, and distant bays, respectively (P = .001). Computation fluid dynamics modeling indicated that the normalized concentration of virus-laden aerosols was highest in the same bay and lowest in the distant bays. Cox regression indicated that staying in the ward on 6 or 10 March entailed higher risk, as well as staying in the same or adjacent bays. The epidemic curve showed 2 peaks, and stratified analyses by bed location suggested >1 generation of spread. Conclusions. The temporal-spatial spread of SARS in the ward was consistent with airborne transmission, as modeled by use of computational fluid dynamics. Infected health care workers likely acted as secondary sources in the latter phase of the outbreak.
has issue date	2005-05-01(xsd:dateTime)
bibo:doi	10.1086/428735
bibo:pmid	15825024
has license	no-cc
sha1sum (hex)	7b8315c3f5d1cd55f61954e29c624a7fe1f9e30a
schema:url	https://doi.org/10.1086/428735
resource representing a document's title	Temporal-Spatial Analysis of Severe Acute Respiratory Syndrome among Hospital Inpatients
has PubMed Central identifier	PMC7107882
has PubMed identifier	15825024
schema:publication	Clin Infect Dis
resource representing a document's body	covid:7b8315c3f5d1cd55f61954e29c624a7fe1f9e30a#body_text
is schema:about of	named entity 'INPATIENTS' named entity 'DISCUSS' named entity 'REPORT' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'HOSPITAL' named entity 'A MAJOR' named entity 'TEMPORAL' named entity 'OUTBREAK' named entity 'HOSPITAL WARD' named entity 'SPATIAL' named entity 'POSSIBLE' named entity 'SPATIAL ANALYSIS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'SPREAD' named entity 'MECHANISMS' named entity 'INPATIENTS' named entity 'TEMPORAL' covid:arg/7b8315c3f5d1cd55f61954e29c624a7fe1f9e30a named entity 'hospital ward' named entity 'SARS' named entity 'nosocomial' named entity 'chronic diseases' named entity 'infection' named entity 'index case' named entity 'virus' named entity 'virus' named entity 'IgG' named entity '24 February' named entity 'chronic disease' named entity 'SARS' named entity '7 March' named entity 'smokers' named entity 'SARS' named entity 'index case' named entity 'probability' named entity 'virus' named entity 'nebulizer' named entity 'Prince of Wales Hospital' named entity 'SARS' named entity 'Hong Kong' named entity 'SARS' named entity 'infection' named entity 'SARS epidemic in 2003' named entity 'nosocomial infection' named entity 'SARS' named entity 'air supply' named entity 'lamivudine' named entity 'aerosols' named entity 'viral hepatitis' named entity 'SARS' named entity 'steroids' named entity 'index case' named entity 'virus' named entity 'statistically insignificant' named entity 'Stratified analysis' named entity 'fever' named entity '9 March' named entity 'index case' named entity 'SARS' named entity 'index case' named entity 'log rank test' named entity 'CFD' named entity 'virus' named entity 'infection' named entity 'nosocomial' named entity 'airborne transmission' named entity 'flow rates' named entity 'SARS' named entity 'virus' named entity 'medical doctor' named entity '10 March' named entity 'virus' named entity 'index case' named entity 'infection' named entity '10 March' named entity 'index case' named entity 'epidemic'

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