About: Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity

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About: Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity
Creator	Ippolito, Giuseppe Agrati, Chiara Bordoni, Veronica Castilletti, Concetta Colavita, Francesca Casetti, Rita Cimini, Eleonora De Minicis, Sara Doria, Margherita Grassi, Germana Sacchi, Alessandra Capobianchi, Maria Desimio, Maria
Source	Medline; PMC
abstract	An expansion of effector/activated Vδ2 T-cells was recently described in acute Zika virus (ZIKV)-infected patients, but their role in the protective immune response was not clarified. The aim of this study was to define the antiviral activity of Vδ2 T-cells against ZIKV-infected cells. The Vδ2 T-cells expansion and their cytotoxic activity against ZIKV-infected cells were tested in vitro and analyzed by RT-PCR and flow cytometry. We found that ZIKV infection was able to induce Vδ2 T-cells expansion and sensitized A549 cells to Vδ2-mediated killing. Indeed, expanded Vδ2 T-cells killed ZIKV-infected cells through degranulation and perforin release. Moreover, ZIKV infection was able to increase the expression on A549 cells of NKG2D ligands (NKG2DLs), namely MICA, MICB, and ULBP2, at both the mRNA and protein levels, suggesting the possible involvement of these molecules in the recognition by NKG2D-expressing Vδ2 T-cells. Indeed, the killing of ZIKV-infected cells by expanded Vδ2 T-cells was mediated by NKG2D/NKG2DL interaction as NKG2D neutralization abrogated Vδ2 cytotoxicity. Our data showed a strong antiviral activity of Vδ2 T-cells against ZIKV-infected cells, suggesting their involvement in the protective immune response. Other studies are necessary to investigate whether the lack of Vδ2 T-cells expansion in vivo may be associated with disease complications.
has issue date	2019-09-12(xsd:dateTime)
bibo:doi	10.3390/microorganisms7090350
bibo:pmid	31547470
has license	cc-by
sha1sum (hex)	7bbe8c4f7a911194a8901fb24e87204b508e7715
schema:url	https://doi.org/10.3390/microorganisms7090350
resource representing a document's title	Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity
has PubMed Central identifier	PMC6781265
has PubMed identifier	31547470
schema:publication	Microorganisms
resource representing a document's body	covid:7bbe8c4f7a911194a8901fb24e87204b508e7715#body_text
is schema:about of	named entity 'studies' named entity 'degranulation' named entity 'antiviral' named entity 'disease' named entity 'T-cells' named entity 'levels' named entity 'MICROORGANISMS' named entity 'CYTOTOXICITY' named entity 'MICB' named entity 'THESE' named entity 'ACUTE' named entity 'EXPANSION' named entity 'ACTIVITY' named entity 'IN VITRO' named entity 'B42' named entity 'DEGRANULATION' named entity 'INDUCE' named entity 'ANALYZED' named entity 'DESCRIBED' named entity 'BUT' named entity 'B42' named entity 'NKG2D' named entity 'MRNA' named entity 'TESTED' named entity 'DATA' named entity 'INVOLVEMENT' named entity 'INFECTED' named entity 'ZIKV' named entity 'T-CELLS' named entity 'INTERACTION' named entity 'CELLS KILLED' named entity 'CLARIFIED' named entity 'TO INVESTIGATE' named entity 'T-CELLS' named entity 'STUDY' named entity 'IMMUNE RESPONSE' named entity 'LIGANDS' named entity 'EXPANDED ' named entity 'ZIKA VIRUS' named entity 'FOUND' named entity 'TO INCREASE' named entity 'A549 CELLS' named entity 'MOLECULES' named entity 'PATIENTS' named entity 'CYTOTOXICITY' named entity 'ULBP2' named entity 'FLOW CYTOMETRY' named entity 'RECOGNITION' named entity 'LACK' named entity 'COMPLICATIONS' named entity 'CELLS' named entity 'STUDIES' named entity 'CYTOTOXIC' named entity 'AIM' named entity 'ANTIVIRAL ACTIVITY' named entity 'THEIR' named entity 'EFFECTOR' named entity 'PROTEIN LEVELS' named entity 'NECESSARY' named entity 'RECENTLY' named entity 'ASSOCIATED WITH' named entity 'DISEASE' named entity 'MICA' named entity 'POSSIBLE' named entity 'OUR' named entity 'EXPRESSION' named entity 'MEDIATED' named entity 'INFECTED' named entity 'MEDIATED'

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