About: Tuberculous pneumonia-induced severe ARDS complicated with DIC in a female child: a case of successful treatment

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About: Tuberculous pneumonia-induced severe ARDS complicated with DIC in a female child: a case of successful treatment Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Tuberculous pneumonia-induced severe ARDS complicated with DIC in a female child: a case of successful treatment
Creator	Ainai, Akira Nakajima, Noriko Kawachi, Shoji Bich, Thuy Phan, Phuc Le, Hai Tran, Minh Hirata, Naoyuki Ngo, Dong
Source	PMC
abstract	BACKGROUND: Tuberculous (TB) pneumonia can induce acute respiratory distress syndrome (ARDS). Although TB pneumonia is one of the causes of disease and death among children worldwide, the literature on TB pneumonia-induced ARDS is limited. We report herein on the successful treatment of a two-year-old female child with TB pneumonia-induced severe ARDS complicated with disseminated intravascular coagulation (DIC). CASE PRESENTATION: A two-year-old Vietnamese female child with sustained fever and cough for 20 days was transferred to our hospital. She had severe dyspnea and a chest X-ray showed bilateral infiltration without findings of heart failure. After tracheal intubation, her oxygenation index (OI) and PaO(2)/FiO(2) (PF) ratio were 29 and 60 mmHg, respectively. Mycobacterium tuberculosis was detected by real-time polymerase chain reaction (rPCR) assay of tracheal lavage fluid. She was diagnosed as having severe ARDS that developed from TB pneumonia. Anti-tuberculous therapy and cardiopulmonary support were started. However, her respiratory condition deteriorated despite treatment with high-frequency oscillating ventilation (HFO), vasopressor support, and 1 g/kg of immunoglobulin. On the third day after admission, her International Society on Thrombosis and Hemostasis DIC score had increased to 5. Recombinant human soluble thrombomodulin (rTM) was administered to treat the DIC. After the administration of rTM was completed, OI gradually decreased, after which the mechanical ventilation mode was changed from HFO to synchronized intermittent mandatory ventilation. The DIC score also gradually decreased. Plasma levels of soluble receptor for advanced glycan end products (sRAGE) and high mobility group box 1 (HMGB-1), which are reported to be associated with ARDS severity, also decreased. In addition, inflammatory biomarkers, including interferon-gamma (IFN-γ) and interleukin-6 (IL-6), decreased after the administration of rTM. Although severe ARDS (P/F ratio ≦ 100 mmHg) continued for 19 days, the patient’s OI and P/F ratio improved gradually, and she was extubated on the 27th day after admission. The severe ARDS with DIC was successfully treated, and she was discharged from hospital on day 33 post-admission. CONCLUSIONS: We successfully treated a female child suffering from TB pneumonia-induced severe ARDS complicated with DIC using multimodal interventions. (338/350).
has issue date	2018-07-03(xsd:dateTime)
bibo:doi	10.1186/s12879-018-3215-5
bibo:pmid	29970013
has license	cc-by
sha1sum (hex)	7c04c87c7cc9018ada3a0ab44432fc31de7ccc36
schema:url	https://doi.org/10.1186/s12879-018-3215-5
resource representing a document's title	Tuberculous pneumonia-induced severe ARDS complicated with DIC in a female child: a case of successful treatment
has PubMed Central identifier	PMC6029363
has PubMed identifier	29970013
schema:publication	BMC Infect Dis
resource representing a document's body	covid:7c04c87c7cc9018ada3a0ab44432fc31de7ccc36#body_text
is schema:about of	named entity 'ratio' named entity 'pneumonia' named entity 'rTM' named entity 'pneumonia' named entity 'DIC' named entity 'oscillating' named entity 'Although' named entity 'child' named entity 'SUSTAINED FEVER' named entity 'VENTILATION MODE' named entity '27S' named entity 'CHILDREN' named entity 'DIC' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'ONE OF' named entity 'INDUCED' named entity 'SUFFERING' named entity 'BACKGROUND' named entity 'ADMINISTERED' named entity 'POST' named entity 'DEATH' named entity 'VIETNAMESE' named entity 'CHEST X-RAY' named entity 'IMMUNOGLOBULIN' named entity 'LIMITED' named entity 'DAYS' named entity 'LITERATURE' named entity 'REAL-TIME POLYMERASE CHAIN REACTION' named entity 'CONCLUSIONS' named entity 'OUR' named entity 'WORLDWIDE' named entity 'HIGH MOBILITY GROUP BOX 1' named entity 'FINDINGS' named entity 'ARDS' named entity 'ventilation' named entity 'inflammatory' named entity 'interferon-gamma' named entity 'interleukin' named entity 'treat' named entity 'female' named entity 'ARDS' named entity 'administration' named entity 'suffering' named entity 'soluble' named entity 'ARDS' named entity 'lavage' named entity 'literature' named entity 'dyspnea' named entity 'fluid' named entity 'Case' named entity 'treated' named entity 'soluble' named entity 'changed' named entity 'cough' named entity 'vasopressor' named entity 'ARDS' named entity 'glycan' named entity 'rPCR' named entity 'International Society' named entity 'ARDS' named entity 'mmHg' named entity 'ARDS' named entity 'DIC' named entity 'respiratory condition' named entity 'ARDS' named entity 'assay' named entity 'Hemostasis' named entity 'Mycobacterium tuberculosis' named entity 'real-time polymerase chain reaction' named entity 'Recombinant' named entity 'ARDS' named entity 'disseminated intravascular coagulation'

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