About: Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children

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About: Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children
Creator	Jin, Dong-Yan Chidlow, Glenys Smith, David Gern, James Bizzintino, Joelene Khoo, Siew-Kim Borland, Meredith Cuthbertson, Leah Franks, Kimberley Prastanti, Franciska Cookson, William Cox, Des Cox, Michael Laingid, Ingrid Le Souë F, Peter Moffatt, Miriam Oo, Stephen
source	Medline; PMC
abstract	Acute viral wheeze in children is a major cause of hospitalisation and a major risk factor for the development of asthma. However, the role of the respiratory tract microbiome in the development of acute wheeze is unclear. To investigate whether severe wheezing episodes in children are associated with bacterial dysbiosis in the respiratory tract, oropharyngeal swabs were collected from 109 children with acute wheezing attending the only tertiary paediatric hospital in Perth, Australia. The bacterial community from these samples was explored using next generation sequencing and compared to samples from 75 non-wheezing controls. No significant difference in bacterial diversity was observed between samples from those with wheeze and healthy controls. Within the wheezing group, attendance at kindergarten or preschool was however, associated with increased bacterial diversity. Rhinovirus (RV) infection did not have a significant effect on bacterial community composition. A significant difference in bacterial richness was observed between children with RV-A and RV-C infection, however this is likely due to the differences in age group between the patient cohorts. The bacterial community within the oropharynx was found to be diverse and heterogeneous. Age and attendance at day care or kindergarten were important factors in driving bacterial diversity. However, wheeze and viral infection were not found to significantly relate to the bacterial community. Bacterial airway microbiome is highly variable in early life and its role in wheeze remains less clear than viral influences.
has issue date	2019-10-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0223990
bibo:pmid	31622414
has license	cc-by
sha1sum (hex)	7c28a8c1dfe1e35116be3903159e5230bd0b9403
schema:url	https://doi.org/10.1371/journal.pone.0223990
resource representing a document's title	Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children
has PubMed Central identifier	PMC6797130
has PubMed identifier	31622414
schema:publication	PLoS One
resource representing a document's body	covid:7c28a8c1dfe1e35116be3903159e5230bd0b9403#body_text
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