About: Neurological Manifestations of Influenza A (H1N1): Clinical Features, Intensive Care Needs, and Outcome

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neurological Manifestations of Influenza A (H1N1): Clinical Features, Intensive Care Needs, and Outcome
Creator	Goyal, Kapil Kumar, Suresh Jayashree, Muralidharan Keshavan, Shivan Nallasamy, Karthi Rk, & Saini, Lokesh Singh, Paramjeet Suthar, Renu Takia, Lalit Verma, Sanjay
Source	PMC
abstract	OBJECTIVES: To describe neurological manifestations in children with Influenza A (H1N1). METHODS: This retrospective study was conducted in the Pediatric intensive care unit (PICU) and Pediatric Neurology unit of a tertiary care teaching hospital in North India involving children with PCR confirmed Influenza A (H1N1) with neurological manifestations during 2019 outbreak. RESULTS: Six children (5 females, 1 male) were enrolled. All presented with neurological symptoms (seizures and altered sensorium) accompanied with fever and respiratory symptoms with duration of illness of 2–7 d. The admission Glasgow Coma Scale ranged from 4 to 12. Only 2 cases showed cerebrospinal fluid pleocytosis. Neuroimaging was suggestive of diffuse cerebral edema, acute necrotizing encephalopathy of childhood, and acute disseminated encephalomyelitis. All were treated with Oseltamivir. Four cases had clinical features of raised intracranial pressure (ICP) and were managed in PICU, 3 of them needed mechanical ventilation, 3 needed vasoactive drugs, 3 received 3% saline infusion, 1 underwent invasive ICP monitoring, and 3 (cases 4, 5 and 6) received intravenous methylprednisolone (30 mg/kg) for 5 d. Total duration of hospital stay was 10–30 d. Case 2 expired due to refractory raised ICP. Among survivors, 3 children had residual neurological deficits and the remaining 2 had achieved premorbid condition. CONCLUSIONS: Influenza A (H1N1) can present with isolated or predominant neurological manifestations which can contribute to poor outcome. The authors suggest to rule out H1N1 in any child who presents with unexplained neurological manifestations during seasonal outbreaks of H1N1.
has issue date	2020-05-02(xsd:dateTime)
bibo:doi	10.1007/s12098-020-03297-w
bibo:pmid	32358785
has license	no-cc
sha1sum (hex)	7c8cb64c98b3b6ea4fbc0d64ccba5006f9a5864b
schema:url	https://doi.org/10.1007/s12098-020-03297-w
resource representing a document's title	Neurological Manifestations of Influenza A (H1N1): Clinical Features, Intensive Care Needs, and Outcome
has PubMed Central identifier	PMC7222163
has PubMed identifier	32358785
schema:publication	Indian J Pediatr
resource representing a document's body	covid:7c8cb64c98b3b6ea4fbc0d64ccba5006f9a5864b#body_text
is schema:about of	named entity 'cases' named entity 'cases' named entity 'Neuroimaging' named entity 'cerebrospinal fluid' named entity 'needed' named entity 'illness' named entity 'Influenza A (H1N1)' named entity 'manifestations' named entity 'RECEIVED' named entity 'DUE TO' named entity 'INVASIVE' named entity 'TOTAL' named entity 'AUTHORS' named entity 'RULE OUT' named entity 'ICP' named entity 'acute disseminated encephalomyelitis' named entity 'raised' named entity 'cases' named entity 'raised intracranial pressure' named entity 'neurological' named entity 'outbreaks' named entity 'neurological' named entity 'managed' named entity 'GCS' named entity 'transaminitis' named entity 'intensive care' named entity 'H1N1' named entity 'retrospective study' named entity 'fever' named entity 'Pediatric intensive care unit' named entity 'brain lesions' named entity 'H1N1' named entity 'prednisolone' named entity 'Pediatric' named entity 'case reports' named entity 'pleocytosis' named entity 'respiratory symptoms' named entity 'CSF' named entity 'self-limiting' named entity 'deep tendon reflexes' named entity 'Oseltamivir' named entity 'index of suspicion' named entity 'cerebral edema' named entity 'pleocytosis' named entity 'CSF' named entity 'mechanical ventilation' named entity 'encephalitis' named entity 'Influenza' named entity 'sequelae' named entity 'Influenza' named entity 'neurological symptoms' named entity 'virological' named entity 'basal ganglia' named entity 'encephalopathy' named entity 'virus' named entity 'influenza' named entity 'sequelae' named entity 'thalamus' named entity 'encephalopathy' named entity 'intravenous' named entity 'respiratory failure' named entity 'cerebral edema' named entity 'encephalitis' named entity 'neurological deficits' named entity 'neuroimaging' named entity 'Influenza' named entity 'meningoencephalitis' named entity 'case reports' named entity 'admission' named entity 'premorbid' named entity 'Four'

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