About: In-hospital Use of Statins is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

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About: In-hospital Use of Statins is Associated with a Reduced Risk of Mortality among Individuals with COVID-19 Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In-hospital Use of Statins is Associated with a Reduced Risk of Mortality among Individuals with COVID-19
Creator	Cheng, Xu Chen, F Yang, Jun Liu, Peter Zhang, Xin Zhou, Feng Liu, Liming Yang, Juan Zhang, Peng Wang, Yibin Xia, L Zhou, M Cai, Jingjing Wang, X Zhang, X Ye, Ping Wei, Xiang Li, J Chen, Guohua Zhang, L Guo, Jiao Chen, P Lin, X Liu, G Liu, P Wang, J Xia, H Xiao, Y Yan, W Yang, J Zhao, J Zhao, L Lu, B Xu, X Yan, Youqin Lei, Y Peng, Z Shen, X Song, L Yang, Huilin Bai, Liangjie Cai, Y Chen, Ming-Ming Ji, Yan-Xiao Li, Hongliang Lin, Lijin Ma, L Lu, Zhigang Ma, Xinliang Mao, L Mao, Weiming Qin, Juan-Juan Rohit, Loomba She, Zhi-Gang Song, Xiaohui Xia, Jiahong Xia, Meng Xu, Qingbo Yuan, Yufeng Zhang, Bing-Hong Zhang, Xiao-Jing Zhu, Lihua Xiao, Bing Zhao, Yan-Ci Zhou, Jianghua Lu, C Yang, Luyu Bai, H Cheng, J.-J Liao, D Liao, Xiaofeng Liu, Minyu Lu, Haofeng Peng, Gang Rohit, P She, J Shen, Lijun Wang, Daihong Xia, Xigang Yang, M.-M Ye, Q Yuan, Y.-C Zhang, B.-H Zhang, Changjiang Zhang, G.-N Zhang, X.-J Zhao, Guang-Nian
source	Elsevier; Medline; PMC
abstract	Summary Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a Cox model with time-varying exposure, as well as a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with a hazard ratio 0.58. These results imply the potential benefits of statin therapy in hospitalized subjects with COVID-19. Further, they give support for the completion of on-going prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic.
has issue date	2020-06-24(xsd:dateTime)
bibo:doi	10.1016/j.cmet.2020.06.015
bibo:pmid	32592657
has license	els-covid
sha1sum (hex)	7ceea3450d77131103adf87d12245e8eb7550499
schema:url	https://doi.org/10.1016/j.cmet.2020.06.015

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