About: Chimpanzee adenoviral vectors as vaccines for outbreak pathogens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
Creator	Lambe, Teresa Ewer, Katie Gilbert, Sarah Sebastian, Sarah Hill, Adrian Spencer, Alexandra
Source	Medline; PMC
abstract	The 2014–15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against outbreak pathogens. Chimpanzee adenoviral (ChAd) vectors have been developed as vaccine candidates for multiple infectious diseases and prostate cancer. ChAd vectors are safe and induce antigen-specific cellular and humoral immunity in all age groups, as well as circumventing the problem of pre-existing immunity encountered with human Ad vectors. For these reasons, such viral vectors provide an attractive platform for stockpiling vaccines for emergency deployment in response to a threatened outbreak of an emerging pathogen. Work is already underway to develop vaccines against a number of other outbreak pathogens and we will also review progress on these approaches here, particularly for Lassa fever, Nipah and MERS.
has issue date	2017-10-30(xsd:dateTime)
bibo:doi	10.1080/21645515.2017.1383575
bibo:pmid	29083948
has license	cc-by
sha1sum (hex)	7d262832606b297d4d1cd2af7a45578d10823418
schema:url	https://doi.org/10.1080/21645515.2017.1383575
resource representing a document's title	Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
has PubMed Central identifier	PMC5718829
has PubMed identifier	29083948
schema:publication	Hum Vaccin Immunother
resource representing a document's body	covid:7d262832606b297d4d1cd2af7a45578d10823418#body_text
is schema:about of	named entity 'adenoviral' named entity 'human' named entity 'infectious diseases' named entity 'adenoviral' named entity 'Chimpanzee' named entity 'vectors' named entity 'OUTBREAK' named entity 'ADENOVIRAL' named entity 'STRATEGIES' named entity 'CAUSED BY' named entity 'EMERGING PATHOGEN' named entity 'EMERGENCY' named entity 'DEPLOYMENT' named entity 'VIRAL VECTORS' named entity 'WEST AFRICA' named entity 'HAVE' named entity 'DEVELOPING' named entity 'IMMUNITY' named entity 'PRE-EXISTING' named entity 'MULTIPLE' named entity 'OUTBREAK' named entity 'REASONS' named entity 'REVIEW' named entity 'HUMORAL IMMUNITY' named entity 'FUTURE' named entity 'AGE GROUPS' named entity 'INDUCE' named entity 'PATHOGENS' named entity 'LARGE' named entity 'PLATFORM' named entity 'VACCINE' named entity 'DISCUSS' named entity 'EPIDEMICS' named entity 'VACCINES' named entity 'POTENTIAL' named entity 'CHAD' named entity 'PROSTATE CANCER' named entity 'PROGRESS' named entity 'RESPONSE TO' named entity 'CHIMPANZEE' named entity 'SAFE' named entity 'WORK' named entity 'ANTIGEN' named entity 'NUMBER OF' named entity 'VECTORS' named entity 'HERE' named entity 'PATHOGENS' named entity 'CELLULAR' named entity 'HUMAN' named entity 'DRIVERS' named entity 'VECTORS' named entity 'LASSA FEVER' named entity 'FOCUS' named entity 'PROVIDE' named entity 'GENERATED' named entity 'CONSIDERATIONS' named entity 'PROBLEM' named entity 'MERS' named entity 'VACCINES' named entity 'DISEASE OUTBREAKS' named entity 'EBOLA' named entity 'CHIMPANZEE' named entity 'APPROACHES' named entity 'INFECTIOUS DISEASES' named entity 'ADENOVIRAL' named entity 'SPECIFIC' named entity 'THESE' named entity 'PREPAREDNESS' named entity 'ATTRACTIVE' covid:arg/7d262832606b297d4d1cd2af7a45578d10823418 named entity 'strategies' named entity 'provide' named entity 'outbreak' named entity 'Nipah' named entity 'Prime-boost' named entity 'immune response'

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