About: Molecular Characterization and Phylogenetic Analysis of Porcine Epidemic Diarrhea Viruses Associated with Outbreaks of Severe Diarrhea in Piglets in Jiangxi, China 2013

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Molecular Characterization and Phylogenetic Analysis of Porcine Epidemic Diarrhea Viruses Associated with Outbreaks of Severe Diarrhea in Piglets in Jiangxi, China 2013 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Characterization and Phylogenetic Analysis of Porcine Epidemic Diarrhea Viruses Associated with Outbreaks of Severe Diarrhea in Piglets in Jiangxi, China 2013
Creator	Wang, Ping Zhang, Chen Chen, Yanjun Huang, Dongyan Huang, Tao Peng, Qi Song, Deping Tang, Yuxin Zhang, Tiansheng He, Houjun Liu, Qinglan Nie, Xiaowei
Source	Medline; PMC
abstract	Porcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), is a highly contagious, acute enteric viral disease of swine characterized by vomiting, watery diarrhea, dehydration and death. To identify and characterize the field PEDVs associated with the outbreaks of severe diarrhea in piglets in Jiangxi, 2013, the complete genome sequences of two representative strains of PEDV, designated CH/JX-1/2013 and CH/JX-2/2013, were determined and analyzed. The genome sequences of both emergent Jiangxi PEDV strains, CH/JX-1/2013 and CH/JX-2/2013, were 28,038 nucleotides in length excluding 3’ poly (A) tail. Compared to the PEDV CV777 strain, CH/JX-1/2013 and CH/JX-2/2013 had some unique genetic characteristics in the proximal region of the 5´-UTRs. Phylogenetic analysis of the complete genomes and the structural proteins revealed that CH/JX-1/2013 and CH/JX-2/2013 had a close relationship with post-2010 Chinese PEDV strains and US strains identified in 2013. The nucleotide identity between the two Jiangxi strains (CH/JX-1/2013 and CH/JX-2/2013) and 30 strains of PEDV identified ante-2010 and post-2010 ranged from 96.3–97.0% and 97.3–99.7%, respectively. Multiple nucleotide and deduced amino acid mutations were observed in the ORF1a/b, S, ORF3, E, M and N genes among the current field PEDV strains when compared to the CV777 strain. Some of the mutations altered the amino acid charge and hydrophilicity, and notably, there was an amino acid substitution in the middle of one neutralizing epitope (L1371I) of the S gene of both CH/JX-1/2013 and CH/JX-2/2013. Taken together, the accumulated genetic variations of the current field PEDV strains might have led to antigenic changes of the viruses, which might confer the less effectiveness or failure of the CV777-based vaccines currently being widely used in Jiangxi, China.
has issue date	2015-03-19(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0120310
bibo:pmid	25790462
has license	cc-by
sha1sum (hex)	7d2bd0d04e9e4418d308e40557a3c397eaada71d
schema:url	https://doi.org/10.1371/journal.pone.0120310
resource representing a document's title	Molecular Characterization and Phylogenetic Analysis of Porcine Epidemic Diarrhea Viruses Associated with Outbreaks of Severe Diarrhea in Piglets in Jiangxi, China 2013
has PubMed Central identifier	PMC4366183
has PubMed identifier	25790462
schema:publication	PLoS One
resource representing a document's body	covid:7d2bd0d04e9e4418d308e40557a3c397eaada71d#body_text
is schema:about of	named entity 'Jiangxi' named entity 'swine' named entity 'genetic variations' named entity 'vaccines' named entity 'highly' named entity 'caused' named entity '2013' named entity 'identify' named entity 'altered' named entity 'identified' named entity 'Characterization' named entity 'Viruses' named entity 'Epidemic' named entity 'PORCINE EPIDEMIC DIARRHEA' named entity 'PHYLOGENETIC ANALYSIS' named entity 'FIELD' named entity 'FAILURE' named entity 'CHANGES' named entity 'REPRESENTATIVE' named entity 'EMERGENT' named entity 'OUTBREAKS' named entity 'CLOSE RELATIONSHIP' named entity 'USED' named entity 'IS A' named entity 'CHARACTERIZATION' named entity 'MULTIPLE' named entity 'ASSOCIATED WITH' named entity 'CHARGE' named entity 'CHARACTERISTICS' named entity 'OBSERVED' named entity 'COMPARED' named entity 'PORCINE EPIDEMIC DIARRHEA' named entity 'VIRUSES' named entity 'GENOMES' named entity 'CURRENT' named entity 'ANALYZED' named entity 'STRUCTURAL PROTEINS' named entity 'ENTERIC' named entity 'CURRENTLY' named entity 'CHINESE' named entity 'NUCLEOTIDES' named entity 'POLY' named entity 'ANTE' named entity 'LENGTH' named entity 'AMINO ACID SUBSTITUTION' named entity 'PROXIMAL REGION' named entity 'GENETIC VARIATIONS' named entity 'CHINA' named entity 'GENOME' named entity '28A' named entity 'GENE' named entity 'VIRAL DISEASE' named entity 'SEVERE DIARRHEA' named entity 'BASED' named entity 'ALTERED' named entity 'POST' named entity 'ORF3' named entity 'HIGHLY' named entity 'LED' named entity 'VIRUSES' named entity 'IDENTIFIED' named entity 'REVEALED' named entity 'OUTBREAKS' named entity 'SEVERE DIARRHEA' named entity 'ASSOCIATED WITH' named entity 'EFFECTIVENESS' named entity 'TAKEN' named entity 'UNIQUE' named entity 'BEING' named entity 'STRAINS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software