About: CT abnormalities evocative of lung infection are associated with lower (18)F-FDG uptake in confirmed COVID-19 patients

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About: CT abnormalities evocative of lung infection are associated with lower (18)F-FDG uptake in confirmed COVID-19 patients Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CT abnormalities evocative of lung infection are associated with lower (18)F-FDG uptake in confirmed COVID-19 patients
Creator	Bahloul, Achraf Karcher, Gilles Mandry, Damien Marie, Pierre-Yves Verger, Antoine Boursier, Caroline Imbert, Laëtitia Jeulin, Hélène
Source	Medline; PMC
abstract	PURPOSE: CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas (18)F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 (18)F-FDG-PET signs in patients that were (i) suspected to have a lung infection based on (18)F-FDG-PET/CT recorded during the COVID-19 outbreak and (ii) whose COVID-19 diagnosis was definitely established or excluded by appropriate viral testing. METHODS: Twenty-two consecutive patients referred for routine (18)F-FDG-PET/CT examinations during the COVID-19 outbreak (March 25th to May 15th 2020) and for whom CT slices were evocative of a lung infection were included in the study. All patients had undergone a SARS-COV-2 diagnostic test to confirm COVID-19 infection (positivity was based on molecular and/or serological tests) or exclude it (negativity of at least the serological test). RESULTS: Eleven patients were confirmed to be affected by COVID-19 (COVID+), whereas the other eleven patients were not (COVID−) and were predominantly suspected of having bacterial pneumonia. CT abnormalities were not significantly different between COVID+ and COVID− groups, although trends toward larger CT abnormalities (p = 0.16) and lower rates of consolidation patterns (0.09) were observed in the COVID+ group. The maximal standardized uptake values (SUV(max)) of lung areas with CT abnormalities were however significantly lower in the COVID+ than the COVID− group (3.7 ± 1.9 vs. 6.9 ± 4.1, p = 0.03), with the highest SUV(max) consistently not associated with COVID-19. CONCLUSION: Among CT abnormalities evocative of lung infection, those related to COVID-19 are associated with a more limited (18)F-FDG uptake. This observation may help improve our ability to detect COVID-19 patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00259-020-04999-1) contains supplementary material, which is available to authorized users.
has issue date	2020-08-18(xsd:dateTime)
bibo:doi	10.1007/s00259-020-04999-1
bibo:pmid	32808079
has license	no-cc
sha1sum (hex)	7d5a63e5cf9ef637446de918280fe41db690ab48
schema:url	https://doi.org/10.1007/s00259-020-04999-1
resource representing a document's title	CT abnormalities evocative of lung infection are associated with lower (18)F-FDG uptake in confirmed COVID-19 patients
has PubMed Central identifier	PMC7431215
has PubMed identifier	32808079
schema:publication	Eur J Nucl Med Mol Imaging
resource representing a document's body	covid:7d5a63e5cf9ef637446de918280fe41db690ab48#body_text
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