About: Pertussis hospitalizations among term and preterm infants: clinical course and vaccine effectiveness

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pertussis hospitalizations among term and preterm infants: clinical course and vaccine effectiveness
Creator	Sanders, Elisabeth De Melker, Hester Baauw, Albertine Westerhof, Anneke Van Der Maas, Nicoline Versteegh, Florens
Source	PMC
abstract	BACKGROUND: Pertussis causes severe disease in young unvaccinated infants, with preterms potentially at highest risk. We studied pertussis in hospitalized infants as related to gestational age (GA) and vaccination history. METHODS: Medical record data of 0-2y old patients hospitalized for pertussis during 2005–2014 were linked to vaccination data. Multivariable logistic regression was used to study the association between GA and vaccination history on the clinical disease course. We compared vaccine effectiveness (VE) against hospitalization for pertussis between term and preterm infants (i.e., <37w GA) using the screening method as developed by Farrington. RESULTS: Of 1187 records, medical data from 676 were retrieved. Of these, 12% concerned preterms, whereas they are 8% of Dutch birth cohorts. Median age at admission was 3 m for preterms and 2 m for terms (p < 0.001). Preterms more often had received pertussis vaccination (62% vs 44%; p = 0.01) and more often had coinfections (37% vs 21%; p = 0.01). Preterms tended more often to have complications, to require artificial respiration or to need admittance to the intensive care unit (ICU). Preterms had longer ICU stays (15d vs 9d; p = 0.004). Vaccinated preterms and terms had a lower median length of hospital stay and lower crude risks of apneas and the need for artificial respiration, additional oxygen, and ICU admittance than those not vaccinated. After adjustment for presence of coinfections and age at admittance, these differences were not significant, except the lower need of oxygen treatment in vaccinated terms. Effectiveness of the first vaccination against pertussis hospitalizations was 95% (95% CI 93–96%) and 73% (95% CI 20–91%) in terms and preterms, respectively. Effectiveness of the second dose of the primary vaccination series was comparable in both groups (86 and 99%, respectively). CONCLUSIONS: Infants hospitalized for pertussis suffer from severe disease. Preterms were overrepresented, with higher need for intensive treatment and less VE of first vaccination. These findings stress the need for alternative prevention, in particular prenatal vaccination of mothers, to reduce pertussis in both groups.
has issue date	2019-10-29(xsd:dateTime)
bibo:doi	10.1186/s12879-019-4563-5
bibo:pmid	31664950
has license	cc-by
sha1sum (hex)	7d9e398e0de06f3fc877f3d67489e798b7c31c20
schema:url	https://doi.org/10.1186/s12879-019-4563-5
resource representing a document's title	Pertussis hospitalizations among term and preterm infants: clinical course and vaccine effectiveness
has PubMed Central identifier	PMC6820906
has PubMed identifier	31664950
schema:publication	BMC Infect Dis
resource representing a document's body	covid:7d9e398e0de06f3fc877f3d67489e798b7c31c20#body_text
is schema:about of	named entity 'VACCINE EFFECTIVENESS' named entity 'hospital' named entity 'length' named entity 'vaccination' named entity 'age' named entity 'stress' named entity 'vaccinated' named entity 'infants' named entity 'hospitalized' named entity 'artificial respiration' named entity 'hospitalizations' named entity 'TERM' named entity 'HOSPITALIZATIONS' covid:arg/7d9e398e0de06f3fc877f3d67489e798b7c31c20 named entity 'VACCINATION AGAINST PERTUSSIS' named entity 'ASSOCIATION' named entity 'GESTATIONAL AGE' named entity 'LOGISTIC REGRESSION' named entity 'TREATMENT' named entity 'PREVENTION' named entity '2886' named entity 'NOT SIGNIFICANT' named entity 'RISK' named entity 'FINDINGS' named entity 'VACCINATION HISTORY' named entity 'VACCINATION' named entity 'RELATED' named entity 'HAVE' named entity 'BIRTH' named entity 'ARTIFICIAL RESPIRATION' named entity 'PERTUSSIS' named entity 'TERMS' named entity 'INTENSIVE CARE UNIT' named entity 'SECOND' named entity 'MEDICAL RECORD' named entity 'EXCEPT' named entity 'OLD' named entity 'VACCINATED' named entity 'THESE' named entity 'CONCLUSIONS' named entity 'COMPARED' named entity 'ADDITIONAL' named entity 'ADJUSTMENT' named entity 'RECORDS' named entity 'CAUSES' named entity 'USING' named entity 'SUFFER' named entity 'STRESS' named entity 'AGE' named entity 'PARTICULAR' named entity 'RISKS' named entity 'LENGTH OF HOSPITAL STAY' named entity 'DATA' named entity 'PRETERM' named entity 'LOWER' named entity 'MEDIAN' named entity 'USED' named entity 'MOTHERS' named entity 'TERM' named entity 'CLINICAL' named entity 'COMPLICATIONS' named entity 'RESULTS' named entity 'DOSE' named entity 'VACCINE EFFECTIVENESS' named entity 'CLINICAL COURSE' named entity 'PERTUSSIS' named entity 'METHODS' named entity '28I' named entity 'ADMITTANCE' named entity 'INFANTS' named entity 'PRIMARY VACCINATION' named entity 'MEDICAL DATA' named entity 'DUTCH' named entity 'YOUNG' named entity 'APNEAS' named entity 'SEVERE DISEASE'

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