About: Lung Histology Predicts Outcome of Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation

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About: Lung Histology Predicts Outcome of Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lung Histology Predicts Outcome of Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation
Creator	Bubendorf, Lukas Gambazzi, Franco Girsberger, Sabine Grendelmeier, Peter Heim, Dominik Holbro, Andreas Hostettler, Katrin Lardinois, Didier Lehmann, Thomas Savic, Spasenija Stern, Martin Tamm, Michael Tichelli, André Passweg, Jakob Halter, Joerg
Source	Elsevier; Medline; PMC
abstract	Bronchiolitis obliterans (BO) is a severe complication after allogeneic hematopoietic stem cell transplantation with an unfavorable prognosis. Lung biopsy remains the gold standard for diagnosis. In this retrospective single-center study, we describe 33 patients who underwent biopsy for suspected BO. Ten patients had constrictive BO (CBO); 9 had lymphocytic bronchiolitis (LB), characterized by lymphocytic infiltration of the bronchioles. Six additional patients (4, CBO; 2, LB) had concomitant infection; 8 had other pathological diagnoses. Seven patients with CBO and 3 with LB met the National Institutes of Health consensus BO syndrome definition criteria. An additional 7 patients with histologically confirmed CBO did not meet the consensus definition, 4 of them because of concomitant airway infection. At diagnosis, there were no significant differences between the CBO and LB groups in clinical presentation; pulmonary function tests (median forced expiratory volume in one second [FEV1] at baseline, 90.4% and 99% predicted, at time of video-assisted thoracoscopic surgery, 55.1% and 60.8% for CBO and LB groups, respectively); and chest scans. Treatment was similar in both groups but outcome was different depending on histological findings. FEV1 significantly improved in LB patients compared with CBO patients. Survivals at 1 and 3 years were 77% ± 12% and 60% ± 14% for patients with CBO and 91% ± 9% for patients with LB (P = .028). Lung biopsy in patients with suspected BO enables better characterization of the pattern of BO syndrome. In contrast to CBO, LB is associated with a good long-term prognosis.
has issue date	2013-04-02(xsd:dateTime)
bibo:doi	10.1016/j.bbmt.2013.03.017
bibo:pmid	23562737
has license	no-cc
sha1sum (hex)	7da3095238b2b79437ff72b316dd1bd9c87969e9
schema:url	https://doi.org/10.1016/j.bbmt.2013.03.017
resource representing a document's title	Lung Histology Predicts Outcome of Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation
has PubMed Central identifier	PMC7110693
has PubMed identifier	23562737
schema:publication	Biol Blood Marrow Transplant
resource representing a document's body	covid:7da3095238b2b79437ff72b316dd1bd9c87969e9#body_text
is schema:about of	named entity 'HISTOLOGY' named entity 'suspected' named entity 'Survivals' named entity 'bronchioles' named entity 'diagnosis' named entity 'FEV1' named entity 'Bronchiolitis obliterans' named entity 'groups' named entity 'enables' named entity 'Lung biopsy' named entity 'CBO' named entity 'Stem Cell' named entity '60%' named entity 'FOR DIAGNOSIS' named entity '28P' named entity 'BUT' named entity 'STUDY' named entity 'INFECTION' named entity 'TIME' named entity 'HISTOLOGICALLY' named entity 'COMPLICATION' named entity 'SEVEN' named entity 'VIDEO-ASSISTED THORACOSCOPIC SURGERY' named entity 'LUNG BIOPSY' named entity 'HEMATOPOIETIC STEM CELL TRANSPLANTATION' named entity 'PATIENTS' named entity 'BIOPSY' named entity 'IS A' named entity 'DID' named entity 'GROUPS' named entity 'NATIONAL INSTITUTES OF HEALTH' named entity 'PROGNOSIS' named entity 'LYMPHOCYTIC INFILTRATION' named entity 'YEARS' named entity 'SURVIVALS' named entity 'TREATMENT' named entity 'BRONCHIOLITIS OBLITERANS SYNDROME' named entity 'LYMPHOCYTIC' named entity 'DESCRIBE' named entity 'SINGLE' named entity 'CLINICAL PRESENTATION' named entity 'RETROSPECTIVE' named entity 'COMPARED' named entity 'UNFAVORABLE' named entity 'BRONCHIOLITIS OBLITERANS SYNDROME' named entity 'BASELINE' named entity 'PULMONARY FUNCTION TESTS' named entity 'CHRONIC GVHD' named entity 'FEV1' named entity 'SECOND' named entity 'ADDITIONAL' named entity 'CRITERIA' named entity 'FINDINGS' named entity 'BRONCHIOLITIS' named entity 'DEFINITION' named entity 'MET' named entity 'LUNG' named entity 'PATTERN' named entity 'PATHOLOGICAL' named entity 'CONSTRICTIVE BRONCHIOLITIS' named entity 'SIGNIFICANT' named entity 'OUTCOME' named entity 'LUNG' named entity 'PREDICTED' named entity 'BETTER' named entity 'SIMILAR' named entity 'GOLD STANDARD'

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