About: Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients
Creator	Zhang, Hong Liu, Kui Qin, Yu Cai, Jiaojiao Ding, Wencheng Gui, Lingli Meng, Yifan Sun, Haiying Huang Id, Liang Huang, Ma Id, Ke Meng, Citation Wu Id, Peng
source	Medline; PMC
abstract	To confirm the relationship between sex and the progression of Coronavirus Disease-19 (COVID-19), and its potential mechanism, among severe patients. For this retrospective study, we included 168 consecutive severe patients with pathogen-confirmed COVID-19 who were hospitalized between January 16th and February 4th, 2020, at Tongji Hospital in Wuhan, China. Clinical characteristics, laboratory parameters, and outcomes were compared and analyzed between males and females. In the present study, we analyzed 168 severe patients with COVID-19, including 86 males and 82 females, and 48 patients (28.6%) were diagnosed as critically ill. Of 86 male patients, 12.8% (11/86) died and 75.6% (65/86) were discharged; of 82 female patients, 7.3% (6/82) died and 86.6% (71/82) were discharged. Eleven laboratory parameters showed significant differences between male and female patients, and six of them were higher during the whole clinical course in patients who died than in patients who were discharged. In adjusted logistic regression analysis, males with comorbidities presented a higher risk of being critically ill than males without comorbidities (OR = 3.824, 95% CI = 1.279–11.435). However, this association attenuated to null in female patients (OR = 2.992, 95% CI = 0.937–9.558). A similar sex-specific trend was observed in the relation between age and critically ill conditions. We highlighted sex-specific differences in clinical characteristics and prognosis. Male patients appeared to be more susceptible to age and comorbidities. Sex is an important biological variable that should be considered in the prevention and treatment of COVID-19.
has issue date	2020-04-28(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1008520
bibo:pmid	32343745
has license	cc-by
sha1sum (hex)	7da72db559c616a430aa3e2d779528f0239e3993
schema:url	https://doi.org/10.1371/journal.ppat.1008520
resource representing a document's title	Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients
has PubMed Central identifier	PMC7209966
has PubMed identifier	32343745
schema:publication	PLoS Pathog
resource representing a document's body	covid:7da72db559c616a430aa3e2d779528f0239e3993#body_text
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