About: Characterization of the major histocompatibility complex class II DOB, DPB1, and DQB1 alleles in cynomolgus macaques of Vietnamese origin

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About: Characterization of the major histocompatibility complex class II DOB, DPB1, and DQB1 alleles in cynomolgus macaques of Vietnamese origin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of the major histocompatibility complex class II DOB, DPB1, and DQB1 alleles in cynomolgus macaques of Vietnamese origin
Creator	Wang, Tao Ling, Fei Zhuo, Min Wang, Hai-Bo Wang, Ju-Fang Wang, Xiao-Ning Wei, Li-Qiong
Source	PMC
abstract	Major histocompatibility complex (MHC) molecules play an important role in the susceptibility and/or resistance to many diseases. To gain an insight into the MHC background and to facilitate the experimental use of cynomolgus macaques, the second exon of the MhcMafa-DOB, -DPB1, and -DQB1 genes from 143 cynomolgus macaques were characterized by cloning to sequencing. A total of 16 Mafa-DOB, 16 Mafa-DPB1, and 34 Mafa-DQB1 alleles were identified, which revealed limited, moderate, and marked allelic polymorphism at DOB, DPB1, and DQB1, respectively, in a cohort of cynomolgus macaques of Vietnamese origin. In addition, 16 Mafa-DOB, 5 Mafa-DPB1, and 8 Mafa-DQB1 alleles represented novel sequences that had not been reported in earlier studies. Almost of the sequences detected at the DOB and DQB1 locus in the present study belonged to DOB01 (100%) and DQB106 (62%) lineages, respectively. Interestingly, four, three, and one high-frequency alleles were detected at Mafa-DOB, -DPB1, and -DQB1, respectively, in this monkeys. The alleles with the highest frequency among these monkeys were Mafa-DOB010102, Mafa-DPB113, and Mafa-DQB1*0616, and these were found in 33 (25.6%) of 129 monkeys, 32 (31.37%) of 102 monkeys, and 30 (31%) of 143 monkeys, respectively. The high-frequency alleles may represent high priority targets for additional characterization of immune function. We also carried out evolutionary and population analyses using these sequences to reveal population-specific alleles. This information will not only promote the understanding of MHC diversity and polymorphism in the cynomolgus macaque but will also increase the value of this species as a model for biomedical research.
has issue date	2010-12-04(xsd:dateTime)
bibo:doi	10.1007/s00251-010-0498-0
bibo:pmid	21132285
has license	no-cc
sha1sum (hex)	7dc1bddc103b21536651896edcf8c90f15c57079
schema:url	https://doi.org/10.1007/s00251-010-0498-0
resource representing a document's title	Characterization of the major histocompatibility complex class II DOB, DPB1, and DQB1 alleles in cynomolgus macaques of Vietnamese origin
has PubMed Central identifier	PMC7080152
has PubMed identifier	21132285
schema:publication	Immunogenetics
resource representing a document's body	covid:7dc1bddc103b21536651896edcf8c90f15c57079#body_text
is schema:about of	named entity 'MHC' named entity 'background' named entity 'DQB1' named entity 'cynomolgus' named entity 'reveal' named entity 'allelic' named entity 'biomedical' named entity 'Vietnamese' named entity '102' named entity 'DETECTED' named entity 'COHORT' named entity 'INCREASE' named entity 'STUDIES' named entity 'IMMUNE FUNCTION' named entity 'MODEL' named entity 'USE OF' named entity 'DISEASES' named entity 'NOVEL' named entity 'SEQUENCES' named entity 'VIETNAMESE' named entity 'GAIN' named entity 'POPULATION' named entity 'SUSCEPTIBILITY' named entity 'DPB1' named entity 'MHC' named entity 'MOLECULES' named entity 'SPECIFIC' named entity 'PLAY' named entity 'IDENTIFIED' named entity 'HIGHEST' named entity 'PROMOTE' named entity 'HIGH PRIORITY' named entity 'INSIGHT' named entity 'ALLELES' named entity '129' named entity 'ADDITION' named entity 'THESE' named entity 'STUDY' named entity 'CYNOMOLGUS MACAQUE' named entity 'USING' covid:arg/7dc1bddc103b21536651896edcf8c90f15c57079 named entity 'TOTAL' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX' named entity 'BACKGROUND' named entity 'CYNOMOLGUS' named entity 'EARLIER' named entity 'MARKED' named entity 'ROLE' named entity 'ALMOST' named entity 'ORIGIN' named entity 'SPECIES' named entity 'CHARACTERIZED' named entity 'LIMITED' named entity 'BUT' named entity 'DOB' named entity 'CHARACTERIZATION' named entity 'VIETNAMESE' named entity 'REPORTED' named entity 'MACAQUES' named entity 'CYNOMOLGUS' named entity 'ALLELES' named entity 'ORIGIN' named entity 'MODERATE' named entity 'DOB' named entity 'LOCUS' named entity '28100' named entity 'REPRESENT' named entity 'REVEALED' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II' named entity 'CARRIED' named entity 'UNDERSTANDING' named entity 'MAFA' named entity 'SECOND' named entity 'IMPORTANT' named entity 'MONKEYS'

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