About: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling

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About: The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
Creator	Stone, Colleen Bell, Rickesha Buhrke, Kaitlin Dickey, Laura Petersen, Charisse Soto, Raymond Yandamuri, Soumya Fujinami, Robert Lane, Thomas Brown, Garrett Gomes-Neto, Joao O'connell, Ryan Pastuzyn, Elissa Round, June Shepherd, Jason Stephens, Zac
Source	PMC
abstract	Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host defense following infection with a neurotropic virus through enhancing microglia function. Germfree mice or animals that receive antibiotics are unable to control viral replication within the brain leading to increased paralysis. Microglia derived from germfree or antibiotic-treated animals cannot stimulate viral-specific immunity and microglia depletion leads to worsened demyelination. Oral administration of toll-like receptor (TLR) ligands to virally infected germfree mice limits neurologic damage. Homeostatic activation of microglia is dependent on intrinsic signaling through TLR4, as disruption of TLR4 within microglia, but not the entire CNS (excluding microglia), leads to increased viral-induced clinical disease. This work demonstrates that gut immune-stimulatory products can influence microglia function to prevent CNS damage following viral infection.
has issue date	2019-07-16(xsd:dateTime)
bibo:doi	10.7554/elife.47117
bibo:pmid	31309928
has license	cc-by
sha1sum (hex)	7ddc27749844ce4dd2695ad282cc21c3f3629eec
schema:url	https://doi.org/10.7554/elife.47117
resource representing a document's title	The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling
has PubMed Central identifier	PMC6634972
has PubMed identifier	31309928
resource representing a document's body	covid:7ddc27749844ce4dd2695ad282cc21c3f3629eec#body_text
is schema:about of	named entity 'CNS' named entity 'enhancing' named entity 'TLR4' named entity 'receive' named entity 'damage' named entity 'neurologic' named entity 'microbiota' covid:arg/7ddc27749844ce4dd2695ad282cc21c3f3629eec named entity 'damage' named entity 'excluding' named entity 'function' named entity 'infection' named entity 'signaling' named entity 'function' named entity 'leads' named entity 'Oral administration' named entity 'limits' named entity 'mice' named entity 'TLR4' named entity 'animals' named entity 'prevent' named entity 'TLR' named entity 'demyelination' named entity 'viral replication' named entity 'commensals' named entity 'antibiotics' named entity 'neurologic' named entity 'toll-like receptor' named entity 'microglia' named entity 'microbes' named entity 'microglia' named entity 'clinical disease' named entity 'neurologic' named entity 'infection' named entity 'LPS' named entity 'infection' named entity 'infection' named entity 'viruses' named entity 'Immune cells' named entity 'Spleens' named entity 'mice' named entity 'white matter' named entity 'CD8+' named entity 'mice' named entity 'homeostasis' named entity 'cytokines' named entity 'TLR' named entity 'PFU' named entity 'PBS' named entity 'mice' named entity 'bone marrow' named entity 'antibiotics' named entity 'virus' named entity 'mouse hepatitis virus' named entity 'gut microbial' named entity 'flow cytometric' named entity 'mice' named entity 'clinical disease' named entity 'CD8 T cells' named entity 'immune cell' named entity 'TLR4' named entity 'CD8+ T cell' named entity 'paralysis' named entity 'ligands' named entity 'demyelination' named entity 'Institutional Animal Care and Use Committee' named entity 'Rag1'

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