About: Bitter‐sweet symphony: glycan–lectin interactions in virus biology

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bitter‐sweet symphony: glycan–lectin interactions in virus biology
Creator	Nauwynck, Hans De Groot, Raoul Pö Hlmann, Stefan Favoreel, Herman Breedam, Van
Source	Medline; PMC
abstract	Glycans are carbohydrate modifications typically found on proteins or lipids, and can act as ligands for glycan‐binding proteins called lectins. Glycans and lectins play crucial roles in the function of cells and organs, and in the immune system of animals and humans. Viral pathogens use glycans and lectins that are encoded by their own or the host genome for their replication and spread. Recent advances in glycobiological research indicate that glycans and lectins mediate key interactions at the virus‐host interface, controlling viral spread and/or activation of the immune system. This review reflects on glycan–lectin interactions in the context of viral infection and antiviral immunity. A short introduction illustrates the nature of glycans and lectins, and conveys the basic principles of their interactions. Subsequently, examples are discussed highlighting specific glycan–lectin interactions and how they affect the progress of viral infections, either benefiting the host or the virus. Moreover, glycan and lectin variability and their potential biological consequences are discussed. Finally, the review outlines how recent advances in the glycan–lectin field might be transformed into promising new approaches to antiviral therapy.
has issue date	2013-12-06(xsd:dateTime)
bibo:doi	10.1111/1574-6976.12052
bibo:pmid	24188132
has license	no-cc
sha1sum (hex)	7df7153e8ffc1acdb336d3a30669cc5ecb8684a5
schema:url	https://doi.org/10.1111/1574-6976.12052
resource representing a document's title	Bitter‐sweet symphony: glycan–lectin interactions in virus biology
has PubMed Central identifier	PMC7190080
has PubMed identifier	24188132
schema:publication	FEMS Microbiol Rev
resource representing a document's body	covid:7df7153e8ffc1acdb336d3a30669cc5ecb8684a5#body_text
is schema:about of	named entity 'advances' named entity 'lectins' named entity 'called' named entity 'pathogens' named entity 'key' named entity 'viral infection' named entity 'activation' named entity 'lipids' named entity 'Influenza A virus' named entity 'Information' named entity 'TRANSFORMED' named entity 'ORGANS' named entity 'VIRAL PATHOGENS' named entity 'INTRODUCTION' named entity 'REPLICATION' named entity 'outlines' named entity 'interface' named entity 'host' named entity 'interactions' named entity 'lectins' named entity 'promising' named entity 'function' named entity 'advances' named entity 'mediate' named entity 'variability' named entity 'ligands' named entity 'virus' named entity 'biological consequences' named entity 'antiviral therapy' named entity 'glycan' named entity 'lectins' named entity 'lipids' named entity 'glycan' named entity 'glycan' named entity 'viral infection' named entity 'rotavirus' named entity 'Bovine' named entity 'cell lines' named entity 'NiV' named entity 'glycosylation' named entity 'glycan' named entity 'gene loci' named entity 'virion' named entity 'DC-SIGN' named entity 'common core' named entity 'glycan' named entity 'glycans' named entity 'cross-linking' named entity 'mannosidases' named entity 'MBL deficiency' named entity 'cell entry' named entity 'hemagglutinin' named entity 'transport proteins' named entity 'Golgi' named entity 'DC-SIGN' named entity 'expression levels' named entity 'DC-SIGN' named entity 'exon' named entity 'hemagglutinin-esterase' named entity 'phenotypes' named entity 'host cells' named entity 'Lectins' named entity 'glycosylation' named entity 'N-glycans' named entity 'sialylated' named entity 'lectin' named entity 'lectins' named entity 'CBAs' named entity 'infection' named entity 'HIV' named entity 'lectin' named entity 'CD4 +' named entity 'virions' named entity 'lectins' named entity 'glycan' named entity 'molecular weight' named entity 'effector'

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