About: A cell‐based high‐throughput protocol to screen entry inhibitors of highly pathogenic viruses with Traditional Chinese Medicines

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About: A cell‐based high‐throughput protocol to screen entry inhibitors of highly pathogenic viruses with Traditional Chinese Medicines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A cell‐based high‐throughput protocol to screen entry inhibitors of highly pathogenic viruses with Traditional Chinese Medicines
Creator	Yang, Yong Cheng, Han Yan, Hui Rong, Rong Du, Rui-Kun Rong, Li-Jun Wang, Peng-Zhan Zhang, Cheng-Bo Zhang, Ying-Ying
Source	Medline; PMC
abstract	Emerging viruses such as Ebola virus (EBOV), Lassa virus (LASV), and avian influenza virus H5N1 (AIV) are global health concerns. Since there is very limited options (either vaccine or specific therapy) approved for humans against these viruses, there is an urgent need to develop prophylactic and therapeutic treatments. Previously we reported a high‐throughput screening (HTS) protocol to identify entry inhibitors for three highly pathogenic viruses (EBOV, LASV, and AIV) using a human immunodeficiency virus–based pseudotyping platform which allows us to perform the screening in a BSL‐2 facility. In this report, we have adopted this screening protocol to evaluate traditional Chinese Medicines (TCMs) in an effort to discover entry inhibitors against these viruses. Here we show that extracts of the following Chinese medicinal herbs exhibit potent anti‐Ebola viral activities: Gardenia jasminoides Ellis, Citrus aurantium L., Viola yedoensis Makino, Prunella vulgaris L., Coix lacryma‐jobi L. var. mayuen (Roman.) Stapf, Pinellia ternata (Thunb.) Breit., and Morus alba L. This study represents a proof‐of‐principle investigation supporting the suitability of this assay for rapid screening TCMs and identifying putative entry inhibitors for these viruses. J. Med. Virol. 89:908–916, 2017. © 2016 Wiley Periodicals, Inc.
has issue date	2016-10-14(xsd:dateTime)
bibo:doi	10.1002/jmv.24705
bibo:pmid	27704591
has license	no-cc
sha1sum (hex)	7dfa9c90539a0f3bdc0e35e0cbdacea63b188dcf
schema:url	https://doi.org/10.1002/jmv.24705
resource representing a document's title	A cell‐based high‐throughput protocol to screen entry inhibitors of highly pathogenic viruses with Traditional Chinese Medicines
has PubMed Central identifier	PMC7167059
has PubMed identifier	27704591
schema:publication	J Med Virol
resource representing a document's body	covid:7dfa9c90539a0f3bdc0e35e0cbdacea63b188dcf#body_text
is schema:about of	named entity 'traditional Chinese Medicines' named entity 'BSL-2' named entity 'represents' named entity 'vaccine' named entity 'Chinese medicinal herbs' named entity 'high-throughput screening' named entity 'HIGHLY' named entity 'PRINCIPLE' named entity 'IDENTIFYING' named entity 'PREVIOUSLY' named entity 'VAR' named entity 'REPORT' named entity 'GLOBAL HEALTH' named entity 'potent' named entity 'AIV' named entity 'Gardenia' named entity 'viral' named entity 'viruses' named entity 'entry inhibitors' named entity 'viruses' named entity 'viruses' named entity 'highly' named entity 'global health' named entity 'EBOV' named entity 'avian influenza virus H5N1' named entity 'viruses' named entity 'LASV' named entity 'BSL-2' named entity 'Citrus aurantium' named entity 'Ebola' named entity 'Entry Inhibitors' named entity 'pathogenic viruses' named entity 'Citrus aurantium' named entity 'vaccines' named entity 'EBOV' named entity 'drug discovery' named entity 'Shandong University of Traditional Chinese Medicine' named entity 'HIV-1' named entity 'genetic diversity' named entity 'Coefficient of variation' named entity 'Prunella vulgaris' named entity 'Pinellia ternata' named entity 'AIV' named entity 'Chinese medicinal herb' named entity 'PBS' named entity 'EBOV' named entity 'Artemisia annua' named entity 'Ebola virus' named entity 'false positives' named entity 'herbal extracts' named entity 'infection' named entity 'skewed distribution' named entity 'entry inhibitors' named entity 'viruses' named entity 'antivirals' named entity 'phosphate-buffered saline' named entity 'AIDS' named entity 'Ebola' named entity 'EnVision' named entity 'Lassa virus' named entity 'etiological' named entity 'major problem' named entity 'PBS' named entity 'virus entry' named entity 'signal-to-noise ratio' named entity 'vector' named entity 'viruses' named entity 'virus' named entity 'viruses' named entity 'Ebola' named entity 'epithelial cell' named entity 'AIV' named entity 'global health'

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