About: Human Immunodeficiency Virus-Associated Diarrhea: Still an Issue in the Era of Antiretroviral Therapy

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About: Human Immunodeficiency Virus-Associated Diarrhea: Still an Issue in the Era of Antiretroviral Therapy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Immunodeficiency Virus-Associated Diarrhea: Still an Issue in the Era of Antiretroviral Therapy
Creator	Schonfeld, Emily Dikman, Andrew Nalinee, • Poles, Michael Srisarajivakul, C
topic	covid:7e136fdfc76cd52435cf224414e8a59fa3eaf227#this
Source	Medline; PMC
abstract	Over half of patients with human immunodeficiency virus (HIV) experience diarrhea that contributes negatively to quality of life and adherence to antiretroviral therapy (ART). Opportunistic infectious agents that cause diarrhea in patients with HIV span the array of protozoa, fungi, viruses, and bacteria. With global use of ART, the incidence of diarrhea because of opportunistic infections has decreased; however, the incidence of noninfectious diarrhea has increased. The etiology of noninfectious diarrhea in patients with HIV is multifactorial and includes ART-associated diarrhea and gastrointestinal damage related to HIV infection (i.e., HIV enteropathy). A basic algorithm for the diagnosis of diarrhea in patients with HIV includes physical examination, a review of medical history, assessment of HIV viral load and CD4+ T cell count, stool microbiologic assessment, and endoscopic evaluation, if needed. For patients with negative diagnostic results, the diagnosis of noninfectious diarrhea may be considered. Pharmacologic options for the treatment of noninfectious diarrhea are primarily supportive; however, the use of many unapproved agents is based on unstudied and anecdotal information. In addition, these agents can be associated with treatment-limiting adverse events (AEs), such as drug–drug interactions with ART regimens, abuse liability, and additional gastrointestinal AEs. Currently, crofelemer, an antisecretory agent, is the only therapy approved in the USA for the symptomatic relief of noninfectious diarrhea in patients with HIV on ART.
has issue date	2015-03-14(xsd:dateTime)
bibo:doi	10.1007/s10620-015-3615-y
bibo:pmid	25772777
has license	no-cc
sha1sum (hex)	7e136fdfc76cd52435cf224414e8a59fa3eaf227
schema:url	https://doi.org/10.1007/s10620-015-3615-y
resource representing a document's title	Human Immunodeficiency Virus-Associated Diarrhea: Still an Issue in the Era of Antiretroviral Therapy
has PubMed Central identifier	PMC4499110
has PubMed identifier	25772777
schema:publication	Dig Dis Sci
resource representing a document's body	covid:7e136fdfc76cd52435cf224414e8a59fa3eaf227#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/7e136fdfc76cd52435cf224414e8a59fa3eaf227
is schema:about of	named entity 'ASSOCIATED' named entity 'enteropathy' named entity 'diarrhea' named entity 'The' named entity 'span' named entity 'CD4' named entity 'diagnosis' named entity 'infection' named entity 'diarrhea' named entity 'Era' named entity 'TREATMENT' named entity 'INFECTIOUS AGENTS' named entity 'HIV' named entity 'BACTERIA.' named entity 'MAY BE' named entity 'ALGORITHM' named entity 'REGIMENS' named entity 'ADVERSE EVENTS' named entity 'ASSOCIATED' named entity 'PHARMACOLOGIC' named entity 'PHYSICAL EXAMINATION' named entity 'REVIEW OF' named entity 'MULTIFACTORIAL' named entity 'PATIENTS' named entity 'SPAN' named entity 'STOOL' named entity 'LIMITING' named entity 'CELL COUNT' named entity 'AGENT' named entity 'DRUG-DRUG INTERACTIONS' named entity 'SYMPTOMATIC RELIEF' named entity 'ADHERENCE' named entity 'INCREASED' named entity 'INCLUDES' named entity 'HIV INFECTION' named entity 'DIARRHEA' named entity 'PROTOZOA' named entity 'ASSOCIATED WITH' named entity 'INCIDENCE' named entity '28I' named entity 'DIARRHEA' named entity 'ISSUE' named entity 'ERA' named entity 'ANTIRETROVIRAL THERAPY' named entity 'FUNGI' named entity 'DECREASED' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'EXPERIENCE' named entity 'GASTROINTESTINAL' named entity 'USE OF' named entity 'THESE' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'CROFELEMER' named entity 'ARRAY' named entity 'VIRUSES' named entity 'OPPORTUNISTIC INFECTIOUS' named entity 'APPROVED' named entity 'ENDOSCOPIC' named entity 'NONINFECTIOUS' named entity 'ADDITIONAL' named entity 'IF NEEDED' named entity 'USA' named entity 'NEGATIVE' named entity 'ANTISECRETORY' named entity 'OPTIONS' named entity 'OPPORTUNISTIC INFECTIONS' named entity 'ART' named entity 'DIAGNOSTIC' named entity 'HIV ENTEROPATHY' named entity 'HIV VIRAL LOAD' named entity 'INFORMATION' named entity 'MEDICAL HISTORY' named entity 'ANTIRETROVIRAL THERAPY' named entity 'DIAGNOSIS' named entity 'QUALITY OF LIFE'

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