About: Point of care nucleic acid testing for SARS-CoV-2 in hospitalised patients: a clinical validation trial and implementation study.

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About: Point of care nucleic acid testing for SARS-CoV-2 in hospitalised patients: a clinical validation trial and implementation study. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Point of care nucleic acid testing for SARS-CoV-2 in hospitalised patients: a clinical validation trial and implementation study.
Creator	Goel, Neha Dougan, Gordon Smith, Kenneth Lee, C Curran, Martin Bradley, John Lee, Helen Smith, J Zhang, M Gupta, Ravindra Siedner, Mark Assennato, S Assennato, Sonny Besser, Martin Collier, D Collier, Dami Curran, N Demiris, Nikos Demiris, V Dougan, M Enoch, David Goel, I Gupta, H Lehner, Paul Lehner, G Leong, Clare Lineham, Michelle Lineham, R Mendoza, K Mendoza, Vivienne Mok, C Mok, Ping Ramsey, A Ramsey, Isobel Ravji, A Ravji, Pooja Ritchie, Allyson Ritchie, K Routledge, Matthew Routledge, P Sharrocks, Katherine Sharrocks, N Siedner, P Sithole, Nyarie Skittrall, Jordan Smielewska, Anna Smielewska, J Sparkes, Dominic Sparkes, M Tassell, Rhys Vaghela, Devan Vaghela, M Waddington, Claire Waddington, H Warne, Ben Zhang, Hongyi
source	Elsevier; Medline; PMC
abstract	Summary There is urgent need for rapid SARS-CoV-2 testing in hospital to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in 149 participants with parallel combined nasal/throat swabbing for POC versus standard lab RT-PCR testing. Median time to result is 2.6 (IQR 2.3 to 4.8) versus 26.4 hours (IQR 21.4 to 31.4, p<0.001) with 32 (21.5%) positive and 117 (78.5%) negative. Cohen's kappa correlation between tests is 0.96 (95%CI 0.91, 1.00). When comparing nearly 1000 tests pre- and post- implementation, median time to definitive bed placement from admission is 23.4 (8.6-41.9) versus 17.1 hours (9.0-28.8), p=0.02. Mean length of stay on COVID-19 ‘holding’ wards is 58.5 versus 29.9 hours (p<0.001). POC testing increases isolation room availability, avoids bed closures, allows discharge to care homes and expedites access to hospital procedures. POC testing could mitigate the impact of COVID-19 on hospital systems.
has issue date	2020-07-15(xsd:dateTime)
bibo:doi	10.1016/j.xcrm.2020.100062
bibo:pmid	32838340
has license	els-covid
sha1sum (hex)	7eb5c45540a7001d9c1e944fbaa1ffdbaddc3b2b
schema:url	https://doi.org/10.1016/j.xcrm.2020.100062
resource representing a document's title	Point of care nucleic acid testing for SARS-CoV-2 in hospitalised patients: a clinical validation trial and implementation study.
has PubMed Central identifier	PMC7362826
has PubMed identifier	32838340
schema:publication	Cell Rep Med
resource representing a document's body	covid:7eb5c45540a7001d9c1e944fbaa1ffdbaddc3b2b#body_text
is schema:about of	named entity 'Journal' named entity 'Point of care' named entity 'nucleic acid' named entity 'interquartile range' named entity 'COVID-19' named entity 'nucleic acid sequence' named entity '1.02' named entity 'nose and throat' named entity 'SARS-CoV-2' named entity 'COVID-19' named entity 'SARS-CoV-2' named entity 'Descriptive analyses' named entity 'infection control' named entity 'Sensitivity and specificity' named entity 'correlation' named entity 'turnaround time' named entity 'epidemic' named entity 'reverse transcription polymerase chain reaction' named entity 'Uganda' named entity 'COVID' named entity 'general hospital' named entity 'SARS' named entity 'care homes' named entity 'sensitivity/specificity' named entity 'STATA' named entity 'case report'

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