About: Age-Related Onset of Obesity Corresponds with Metabolic Dysregulation and Altered Microglia Morphology in Mice Deficient for Ifitm Proteins

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About: Age-Related Onset of Obesity Corresponds with Metabolic Dysregulation and Altered Microglia Morphology in Mice Deficient for Ifitm Proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Age-Related Onset of Obesity Corresponds with Metabolic Dysregulation and Altered Microglia Morphology in Mice Deficient for Ifitm Proteins
Creator	Gahring, Lorise Rogers, Scott Weis, Janis Weis, John Shen Wee, Yin
Source	PMC
abstract	The IfitmDel mouse lacks all five of the Ifitm genes via LoxP deletion. This animal breeds normally with no obvious defect in development. The IfitmDel animals exhibit a steady and significantly enhanced weight gain relative to wild-type controls beginning about three months of age and under normal feeding conditions. The increased weight corresponds with elevated fat mass, and in tolerance tests they are hyporesponsive to insulin but respond normally to glucose. Both young (4 mo) and older (12 mo) IfitmDel mice have enhanced levels of serum leptin suggesting a defect in leptin/leptin receptor signaling. Analysis of the gene expression profiles in the hypothalamus of IfitmDel animals, compared to WT, demonstrated an altered ratio of Pomc and Npy neuropeptide expression, which likely impairs the satiation response of the IfitmDel animal leading to an increased eating behavior. Also elevated in hypothalamus of IfitmDel mice were pro-inflammatory cytokine expression and reduced IL-10. Anatomical analysis of the hypothalamus using immunohistochemistry revealed that microglia exhibit an abnormal morphology in IfitmDel animals and respond abnormally to Poly:IC challenge. These abnormalities extend the phenotype of the IfitmDel mouse beyond abnormal responses to viral challenge to include a metabolic phenotype and weight gain. Further, this novel phenotype for the IfitmDel mouse could be related to abnormal neuropeptide production, inflammatory status and microglia status in the hypothalamus.
has issue date	2015-04-09(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0123218
bibo:pmid	25856311
has license	cc0
sha1sum (hex)	7ed7b23c66b9c4ad156f37619f8b88bc1c1e996b
schema:url	https://doi.org/10.1371/journal.pone.0123218
resource representing a document's title	Age-Related Onset of Obesity Corresponds with Metabolic Dysregulation and Altered Microglia Morphology in Mice Deficient for Ifitm Proteins
has PubMed Central identifier	PMC4391874
has PubMed identifier	25856311
schema:publication	PLoS One
resource representing a document's body	covid:7ed7b23c66b9c4ad156f37619f8b88bc1c1e996b#body_text
is schema:about of	named entity 'MICROGLIA' named entity 'weight gain' named entity 'abnormal' named entity 'responses' named entity 'weight gain' named entity 'reduced' named entity 'mass' named entity 'mice' named entity 'These' named entity 'mouse' named entity 'mouse' named entity 'Onset' named entity 'AGE' covid:arg/7ed7b23c66b9c4ad156f37619f8b88bc1c1e996b named entity 'POMC' named entity 'ELEVATED' named entity 'RESPOND' named entity 'PHENOTYPE' named entity 'TOLERANCE' named entity 'LEVELS' named entity 'ALTERED' named entity 'USING' named entity 'YOUNG' named entity 'NOVEL' named entity 'MICE' named entity 'LIKELY' named entity 'INFLAMMATORY' named entity 'DELETION' named entity 'THREE MONTHS' named entity 'AGE' named entity 'INCREASED' named entity 'TESTS' named entity 'COULD BE' named entity 'HAVE' named entity 'CONDITIONS' named entity 'GENES' named entity 'VIRAL' named entity 'IL-10' named entity 'NEUROPEPTIDE' named entity 'INSULIN' named entity 'CYTOKINE EXPRESSION' named entity 'WEIGHT GAIN' named entity 'ANIMAL' named entity 'RESPONSE' named entity 'LEADING' named entity 'ABNORMAL' named entity 'ANALYSIS' named entity 'BUT' named entity 'ANIMALS' named entity 'ABNORMALITIES' named entity 'PRO-INFLAMMATORY CYTOKINE' named entity 'BREEDS' named entity 'RESPONSES' named entity 'COMPARED' named entity 'RECEPTOR SIGNALING' named entity 'EATING BEHAVIOR' named entity 'MOUSE' named entity 'POLY' named entity 'LACKS' named entity 'PRODUCTION' named entity 'RELATIVE TO' named entity 'MORPHOLOGY' named entity 'ONSET OF' named entity 'BEGINNING' named entity 'ALTERED' named entity 'DEFICIENT' named entity 'METABOLIC' named entity 'PROTEINS' named entity 'MICE' named entity 'RELATED' named entity 'REVEALED' named entity 'METABOLIC PHENOTYPE' named entity 'THESE' named entity 'GLUCOSE' named entity 'STATUS' named entity 'IMPAIRS' named entity 'BEYOND'

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