About: The TARGET cohort study protocol: a prospective primary care cohort study to derive and validate a clinical prediction rule to improve the targeting of antibiotics in children with respiratory tract illnesses

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About: The TARGET cohort study protocol: a prospective primary care cohort study to derive and validate a clinical prediction rule to improve the targeting of antibiotics in children with respiratory tract illnesses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The TARGET cohort study protocol: a prospective primary care cohort study to derive and validate a clinical prediction rule to improve the targeting of antibiotics in children with respiratory tract illnesses
Creator	Little, Paul Muir, Peter Thompson, Matthew Vipond, Barry Christensen, Hannah Davies, Rachel Delaney, Brendan Fletcher, Margaret Thornton, Hannah Blair, Peter Hay, Alastair Leeming, John Lovering, Andrew Peters, Tim Redmond, Niamh
Source	Medline; PMC
abstract	BACKGROUND: Children with respiratory tract infections are the single most frequent patient group to make use of primary care health care resources. The use of antibiotics remains highly prevalent in young children, but can lead to antimicrobial resistance as well as reinforcing the idea that parents should re-consult for similar symptoms. One of the main drivers of indiscriminate antimicrobial use is the lack of evidence for, and therefore uncertainty regarding, which children are at risk of poor outcome. This paper describes the protocol for the TARGET cohort study, which aims to derive and validate a clinical prediction rule to identify children presenting to primary care with respiratory tract infections who are at risk of hospitalisation. METHODS/DESIGN: The TARGET cohort study is a large, multicentre prospective observational study aiming to recruit 8,300 children aged ≥3 months and <16 years presenting to primary care with a cough and respiratory tract infection symptoms from 4 study centres (Bristol, London, Oxford and Southampton). Following informed consent, symptoms, signs and demographics will be measured. In around a quarter of children from the Bristol centre, a single sweep, dual bacterial-viral throat swab will be taken and parents asked to complete a symptom diary until the child is completely well or for 28 days, whichever is sooner. A review of medical notes including clinical history, re-consultation and hospitalisations will be undertaken. Multivariable logistic regression will be used to identify the independent clinical predictors of hospitalisation as well as the prognostic significance of upper respiratory tract microbes. The clinical prediction rule will be internally validated using various methods including bootstrapping. DISCUSSION: The clinical prediction rule for hospitalisation has the potential to help identify a small group of children for hospitalisation and a much larger group where hospitalisation is very unlikely and antibiotic prescribing would be less warranted. This study will also be the largest natural history study to date of children presenting to primary care with acute cough and respiratory tract infections, and will provide important information on symptom duration, re-consultations and the microbiology of the upper respiratory tract.
has issue date	2013-08-17(xsd:dateTime)
bibo:doi	10.1186/1472-6963-13-322
bibo:pmid	23958109
has license	cc-by
sha1sum (hex)	7f9e15b30bfa7b75a43c5d9febf1b6f71240f80b
schema:url	https://doi.org/10.1186/1472-6963-13-322
resource representing a document's title	The TARGET cohort study protocol: a prospective primary care cohort study to derive and validate a clinical prediction rule to improve the targeting of antibiotics in children with respiratory tract illnesses
has PubMed Central identifier	PMC3765099
has PubMed identifier	23958109
schema:publication	BMC Health Serv Res
resource representing a document's body	covid:7f9e15b30bfa7b75a43c5d9febf1b6f71240f80b#body_text
is schema:about of	named entity 'remains' named entity 'RESPIRATORY TRACT INFECTIONS' covid:arg/7f9e15b30bfa7b75a43c5d9febf1b6f71240f80b named entity 'PARENTS' named entity 'FREQUENT' named entity 'EVIDENCE FOR' named entity 'CHILDREN' named entity 'GROUP' named entity 'CLINICAL PREDICTION RULE' named entity 'MAKE' named entity 'ANTIBIOTICS' named entity 'HOSPITALISATION' named entity 'CONSULT' named entity 'SYMPTOMS' named entity 'ANTIMICROBIAL' named entity 'SIMILAR' named entity 'ANTIMICROBIAL RESISTANCE' named entity 'MAIN' named entity 'AIMS' named entity 'LACK' named entity 'CARE HEALTH' named entity 'POOR OUTCOME' named entity 'HEALTH CARE RESOURCES' named entity 'RISK OF' named entity 'LEAD' named entity 'PRESENTING' named entity 'COHORT STUDY' named entity 'TO IDENTIFY' named entity 'PATIENT' named entity 'PROTOCOL' named entity 'HIGHLY' named entity 'USE' named entity 'IDEA' named entity 'ONE OF' named entity 'UNCERTAINTY' named entity 'BACKGROUND' named entity 'PAPER' named entity 'PRIMARY CARE' named entity 'TARGET' named entity 'INDISCRIMINATE' named entity 'AT RISK' named entity 'YOUNG CHILDREN' named entity 'PREVALENT' named entity 'SINGLE' named entity 'OF EVIDENCE' named entity 'USE OF' named entity 'BUT' named entity 'DRIVERS' named entity 'lead' named entity 'group' named entity 'describes' named entity 'antimicrobial' named entity 'clinical prediction rule' named entity 'lack of evidence' named entity 'health care' named entity 'Antimicrobial' named entity 'asthma' named entity 'prognosis' named entity 'symptom' named entity 'positive and negative predictive values' named entity 'antimicrobial' named entity 'Respiratory tract infections' named entity 'London' named entity 'intravenous fluids' named entity 'validation dataset' named entity 'signs and symptoms' named entity 'splenectomy'

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