About: Role of Podocyte Injury in Glomerulosclerosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Role of Podocyte Injury in Glomerulosclerosis
Creator	Zhang, Yang Lu, Jian Wang, Gui-Hua Chen, Pei-Pei Hu, Ze-Bo Lu, Chen-Chen Ma, Kun-Ling
Source	PMC
abstract	Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to a living environment of various stresses and pathological stimuli, podocytes are prone to injuries; moreover, as a cell without proliferative potential, loss of podocytes is vital in the pathogenesis of glomerulosclerosis. Thus, sufficient understanding of factors and underlying mechanisms of podocyte injury facilitates the advancement of treating and prevention of glomerulosclerosis. The clinical symptom of podocyte injury is proteinuria, sometimes with loss of kidney functions progressing to glomerulosclerosis. Injury-induced changes in podocyte physiology and function are actually not a simple passive process, but a complex interaction of proteins that comprise the anatomical structure of podocytes at molecular levels. This chapter lists several aspects of podocyte injuries along with potential mechanisms, including glucose and lipid metabolism disorder, hypertension, RAS activation, micro-inflammation, immune disorder, and other factors. These aspects are not technically separated items, but intertwined with each other in the pathogenesis of podocyte injuries.
has issue date	2019-06-19(xsd:dateTime)
bibo:doi	10.1007/978-981-13-8871-2_10
bibo:pmid	31399967
has license	no-cc
sha1sum (hex)	7fb5ddcdc15d2c57d11682ae7acc822fe2fb7363
schema:url	https://doi.org/10.1007/978-981-13-8871-2_10
resource representing a document's title	Role of Podocyte Injury in Glomerulosclerosis
has PubMed Central identifier	PMC7120923
has PubMed identifier	31399967
schema:publication	Renal Fibrosis: Mechanisms and Therapies
resource representing a document's body	covid:7fb5ddcdc15d2c57d11682ae7acc822fe2fb7363#body_text
is schema:about of	named entity 'proliferative' named entity 'immune disorder' named entity 'passive' named entity 'stresses' named entity 'potential' named entity 'Glomerulosclerosis' named entity 'Podocyte' named entity 'CHAPTER' named entity 'A CELL' named entity 'TARGETS' named entity 'PODOCYTES' named entity 'FUNCTION' named entity 'therapeutic' named entity 'podocyte' named entity 'targets' named entity 'injuries' named entity 'function' named entity 'Thus' named entity 'glomerulosclerosis' named entity 'hypertension' named entity 'glucose' named entity 'proteinuria' named entity 'podocytes' named entity 'podocyte' named entity 'podocyte' named entity 'podocyte' named entity 'anatomical structure' named entity 'mTOR' named entity 'negative feedback loops' named entity 'mouse models' named entity 'ABCA1' named entity 'RAS' named entity 'antibody' named entity 'proinflammatory' named entity 'TLR' named entity 'EMT' named entity 'CRP' named entity 'hypoxia' named entity 'autophagy' named entity 'reactive oxygen species' named entity 'GBM' named entity 'podocytes' named entity 'acute-phase reactant' named entity 'Nephrin' named entity 'glomerulus' named entity 'interact' named entity 'knockout mice' named entity 'leukocyte' named entity 'bacteriocin' named entity 'epithelial mesenchymal transition' named entity 'hypertrophy' named entity 'physiological' named entity 'tissue damage' named entity 'Tanji' named entity 'ICAM-1' named entity 'muramyl dipeptide' named entity 'membranous nephropathy' named entity 'intracellular' named entity 'Podocytes' named entity 'podocyte' named entity 'nephron' named entity 'fenestrae' named entity 'ANG' named entity 'podocyte' named entity 'peptide' named entity 'podocytes' named entity 'GBM' named entity 'cell body' named entity 'podocyte' named entity 'renin' named entity 'BiP' named entity 'podocytes' named entity 'depolarization' named entity 'BiP' named entity 'podocyte'

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