About: The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer

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About: The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
Creator	Christiansen, Anders Dyrskjøt, Lars
topic	covid:7fc6742c367064839ae23cf1fce7be06aa3501b7#this
source	Elsevier; Medline; PMC
abstract	Abstract In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in cancer cells, where KPNA2 deregulation has been demonstrated to affect malignant transformation. By virtue of its role in nucleocytoplasmic transport, KPNA2 is implicated in the translocation of several cancer-associated proteins. We provide an overview of the clinical studies that have established the biomarker potential of KPNA2 and describe its functional role with an emphasis on established associations with cancer.
has issue date	2013-04-30(xsd:dateTime)
bibo:doi	10.1016/j.canlet.2012.12.013
bibo:pmid	23268335
has license	els-covid
sha1sum (hex)	7fc6742c367064839ae23cf1fce7be06aa3501b7
schema:url	https://doi.org/10.1016/j.canlet.2012.12.013
resource representing a document's title	The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer
has PubMed Central identifier	PMC7126488
has PubMed identifier	23268335
schema:publication	Cancer Letters
resource representing a document's body	covid:7fc6742c367064839ae23cf1fce7be06aa3501b7#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/7fc6742c367064839ae23cf1fce7be06aa3501b7
is schema:about of	named entity 'biomarker' named entity 'CANCER' named entity 'KARYOPHERIN' named entity 'FUNCTIONAL ROLE' named entity 'NOVEL' named entity 'REVIEW' named entity 'MINI' named entity 'BIOMARKER' named entity 'KPNA2' named entity 'metastases' named entity 'oxidative stress' named entity 'prognostic factor' named entity 'Kaiso' named entity 'BRCA1' named entity 'upregulated' named entity 'HPV' named entity 'protein' named entity 'Cellular processes' named entity 'oxidative stress' named entity 'BRCA1' named entity 'translocation' named entity 'carcinogenesis' named entity 'adenosine' named entity 'karyopherin' named entity 'RanGTP' named entity 'KPNA2' named entity 'SARS coronavirus' named entity 'KPNA2' named entity 'interaction partners' named entity 'kDa' named entity 'KPNA2' named entity 'lung cancer' named entity 'KPNA2' named entity 'KPNA2' named entity 'cell cycle checkpoint' named entity 'host specificity' named entity 'malignant transformation' named entity 'B-cell' named entity 'protein' named entity 'KPNA2' named entity 'STAT1' named entity 'RNA' named entity 'KPNA2' named entity 'tumor stage' named entity 'karyopherins' named entity 'nuclear translocation' named entity 'KPNA2' named entity 'UV irradiation' named entity 'KPNA2' named entity 'Nuclear Pore Complexes' named entity 'importin' named entity 'ductal carcinoma in situ' named entity 'KPNA2' named entity 'KPNA2' named entity 'BRCA1' named entity 'KPNA2' named entity 'interaction partners' named entity 'biomarker' named entity 'therapeutic target' named entity 'nuclear localization signal' named entity 'KPNA2' named entity 'KPNA2' named entity 'RAG-1' named entity 'ion transport' named entity 'Importin' named entity 'androgen receptor' named entity 'WAF1' named entity 'cytoplasm' named entity 'KPNA2' named entity 'viruses' named entity 'carcinogenesis' named entity 'metabolic' named entity 'Oct4' named entity 'KPNA2' named entity 'bladder cancer' named entity 'KPNA2' named entity 'prostate cancer' named entity 'p53'

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