About: A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies

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About: A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies
Creator	Perlman, Stanley Diamond, Michael Schmitz, J Case, James Chen, R Ellebedy, Ali Fox, Julie Fremont, Daved Hassan, Ahmed Mccray, Paul Thackray, Larissa Hassan, A Holtzman, Michael Lei, A Lei, Tingting Mccune, Broc Winkler, Emma Kafai, Natasha Bursky, Jane Al 7 Soussi, Wafaa Al Soussi, Wafaa Bailey, A Bailey, Adam Case, J Chen, Rita Fox, J Greco, D Greco, Suellen Holtzman, S Kafai, Kafai, N Keeler, Keeler, S Keeler, Shamus Schmitz, Aaron Shrihari, Swathi Shrihari, T Soussi, Al Thackray, L Turner, Jackson Winkler, E
Source	Elsevier; Medline; PMC
abstract	Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of potential therapies and vaccines to inhibit SARS-CoV-2 infection and ameliorate disease is the lack of susceptible small animals in large numbers. Commercially available laboratory strains of mice are not readily infected by SARS-CoV-2 because of species-specific differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Here, we transduced replication-defective adenoviruses encoding human ACE2 via intranasal administration into BALB/c mice and established receptor expression in lung tissues. hACE2-transduced mice were productively infected with SARS-CoV-2, and this resulted in high viral titers in the lung, lung pathology, and weight loss. Passive transfer of a neutralizing monoclonal antibody reduced viral burden in the lung and mitigated inflammation and weight loss. The development of an accessible mouse model of SARS-CoV-2 infection and pathogenesis will expedite the testing and deployment of therapeutics and vaccines.
has issue date	2020-06-10(xsd:dateTime)
bibo:doi	10.1016/j.cell.2020.06.011
bibo:pmid	32553273
has license	els-covid
sha1sum (hex)	7fc7186f7204e378f3a6737423ab5b6af621a42a
schema:url	https://doi.org/10.1016/j.cell.2020.06.011
resource representing a document's title	A SARS-CoV-2 infection model in mice demonstrates protection by neutralizing antibodies
has PubMed Central identifier	PMC7284254
has PubMed identifier	32553273
schema:publication	Cell
resource representing a document's body	covid:7fc7186f7204e378f3a6737423ab5b6af621a42a#body_text
is schema:about of	named entity 'ACE2' named entity 'infection' named entity 'vaccines' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'infection' named entity 'antibodies' named entity 'AdV' named entity 'lung' named entity 'mice' named entity 'plasmid' named entity 'chemokines' named entity 'SARS-CoV' named entity 'mice' named entity 'SARS-CoV-2' named entity 'mice' named entity 'AdV' named entity 'transduced' named entity 'antibody' named entity 'AdV' named entity 'IgG1' named entity 'infection' named entity 'BALB/c' named entity 'plaque assay' named entity 'serum' named entity 'SARS-CoV-2' named entity 'IFN-β' named entity 'antibody' named entity 'bronchioles' named entity 'SARS-CoV-2' named entity 'inflammation' named entity 'staining' named entity 'Ifnar1' named entity 'protein' named entity 'infection' named entity 'gene' named entity 'lung' named entity 'spleen' named entity 'mice' named entity 'mAb' named entity 'mice'

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