About: Human IgG neutralizing monoclonal antibodies block SARS-CoV-2 infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Human IgG neutralizing monoclonal antibodies block SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human IgG neutralizing monoclonal antibodies block SARS-CoV-2 infection
Creator	Xie, Youhua Xu, Jianqing Yuan, Songhua Zhang, Xiaoyan Ying, Tianlei Wu, Yanling Wang, Yongheng Zhao, Chen Wang, T Zhang, J Wang, L Wang, X Zhu, Dandan Lu, Yanan Wang, Haibin Li, Cheng Wu, C Wang, Xiangxi Chen, Kun Chen, S Gao, L Lan, Fei Li, B Lu, Y Wang, C Xie, Lan, J Zhao, C Gu, Chenjian He, Chenxi Ding, Longfei Gao, Zhangzhao Gu, Y Jiao, Jingyu Nie, C Nie, Lei Qiu, Chengli Rong, Bowen Rong, Y Wan, Jinkai Wang, Siqing Xie, H Xing, Shenghui
Source	Elsevier; Medline; PMC
abstract	Summary COVID-19 has become a worldwide threat to humans, and neutralizing antibodies have therapeutic potential. We have purified more than one thousand memory B cells specific to SARS-CoV-2 S1 or RBD (receptor binding domain), and obtain 729 paired heavy and light chain fragments. Among these, 178 antibodies test positive for antigen binding, and the majority of the top 17 binders with EC50 below 1 nM are RBD binders. Furthermore, we identify 11 neutralizing antibodies, 8 of which show an IC50 within 10 nM, and the best one, 414-1, with IC50 of 1.75 nM. Through epitope mapping, we find 3 main epitopes in RBD recognized by these antibodies, and epitope B antibody 553-15 could substantially enhance the neutralizing abilities of most of the other antibodies. We also find that 515-5 could cross-neutralize the SARS-CoV pseudovirus. Altogether, our study provides 11 potent human neutralizing antibodies for COVID-19 as therapeutic candidates.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2020.107918
bibo:pmid	32668215
has license	els-covid
sha1sum (hex)	7fddfe37d98a8e20ad6357fc68bab068eb72d720
schema:url	https://doi.org/10.1016/j.celrep.2020.107918
resource representing a document's title	Human IgG neutralizing monoclonal antibodies block SARS-CoV-2 infection
has PubMed Central identifier	PMC7332464
has PubMed identifier	32668215
schema:publication	Cell Rep
resource representing a document's body	covid:7fddfe37d98a8e20ad6357fc68bab068eb72d720#body_text
is schema:about of	named entity 'humans' named entity 'therapeutic' named entity 'neutralizing antibodies' named entity 'neutralizing' named entity 'HEAVY' named entity '729' named entity 'SARS-CoV-2' named entity 'RBD' named entity 'memory' named entity 'antibody' named entity 'neutralizing antibodies' named entity 'antibodies' named entity 'antibodies' named entity 'epitopes' named entity 'antibodies' named entity 'epitope' named entity 'antibody' named entity 'epitope' named entity 'RBD' named entity 'neutralizing antibodies' named entity 'SARS-CoV-2' named entity 'CDR3' named entity 'reverse transcription' named entity 'binding affinity' named entity 'antibodies' named entity 'antibodies' named entity 'RBD' named entity 'clones' named entity 'IGH' named entity 'protein' named entity 'Phycoerythrin' named entity 'Epitope' named entity 'antibody' named entity 'ACE2' named entity 'HEK293T' named entity 'neutralizing antibodies' named entity 'ACE2' named entity 'cloned' named entity 'antibodies'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software