About: COVID-19: Therapeutics and Their Toxicities

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About: COVID-19: Therapeutics and Their Toxicities Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	COVID-19: Therapeutics and Their Toxicities
Creator	Barbuto, Alexander Burns, Michele Chary, Michael Hayes, Bryan Izadmehr, Sudeh
topic	covid:7ff99de4d85558cfa209e25767e5b028728bab90#this
source	Medline; PMC
abstract	SARS-CoV-2 is a novel coronavirus that emerged in 2019 and is causing the COVID-19 pandemic. There is no current standard of care. Clinicians need to be mindful of the toxicity of a wide variety of possibly unfamiliar substances being tested or repurposed to treat COVID-19. The United States Food and Drug Administration (FDA) has provided emergency authorization for the use of chloroquine and hydroxychloroquine. These two medications may precipitate ventricular dysrhythmias, necessitating cardiac and electrolyte monitoring, and in severe cases, treatment with epinephrine and high-doses of diazepam. Recombinant protein therapeutics may cause serum sickness or immune complex deposition. Nucleic acid vaccines may introduce mutations into the human genome. ACE inhibitors and ibuprofen have been suggested to exacerbate the pathogenesis of COVID-19. Here, we review the use, mechanism of action, and toxicity of proposed COVID-19 therapeutics.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1007/s13181-020-00777-5
bibo:pmid	32356252
has license	no-cc
sha1sum (hex)	7ff99de4d85558cfa209e25767e5b028728bab90
schema:url	https://doi.org/10.1007/s13181-020-00777-5
resource representing a document's title	COVID-19: Therapeutics and Their Toxicities
has PubMed Central identifier	PMC7192319
has PubMed identifier	32356252
schema:publication	J Med Toxicol
resource representing a document's body	covid:7ff99de4d85558cfa209e25767e5b028728bab90#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/7ff99de4d85558cfa209e25767e5b028728bab90
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