About: Hepatitis C virus and host cell nuclear transport machinery: a clandestine affair

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hepatitis C virus and host cell nuclear transport machinery: a clandestine affair
Creator	Palù, Giorgio Moriishi, Kohji Alvisi, Gualtiero Bonamassa, Barbara Ciccarese, Francesco Contarini, Andrea Antonio, Veronica Walker, Erin
Source	PMC
abstract	There is growing evidence that factors encoded by cytoplasmic replicating viruses functionally interact with components of the nucleocytoplasmic transport apparatus. They do so either to access the cell nucleus, thus affecting genes expression, or to interfere with nuclear transport functionality, hindering host immune response. Recent studies revealed that the hepatitis C virus (HCV) makes no exception, interacting with the host cell nuclear transport machinery at two different levels. On the one hand, small amounts of both core and NS5A localize within the host cell nucleus during productive infection, modulating gene expression and signaling functions to promote persistent infection. On the other hand, HCV infection causes a profound redistribution of certain nucleoproteins to the close proximity of endoplasmic reticulum membrane-derived viral replication factories, where viral RNA amplification occurs. These nucleoporins are believed to form nuclear pore complex-like structures, as suggested by their ability to recruit nuclear localization sequence-bearing proteins. Thus, both processes are linked to virus-induced persistence and pathogenesis, representing possible targets for the development of novel anti-HCV therapeutics.
has issue date	2015-06-19(xsd:dateTime)
bibo:doi	10.3389/fmicb.2015.00619
bibo:pmid	26150811
has license	cc-by
sha1sum (hex)	802ec789744669d95c380885412457a648a10e0d
schema:url	https://doi.org/10.3389/fmicb.2015.00619
resource representing a document's title	Hepatitis C virus and host cell nuclear transport machinery: a clandestine affair
has PubMed Central identifier	PMC4472997
has PubMed identifier	26150811
schema:publication	Front Microbiol
resource representing a document's body	covid:802ec789744669d95c380885412457a648a10e0d#body_text
is schema:about of	named entity 'MINI' named entity 'NUCLEAR TRANSPORT' named entity 'host' named entity 'infection' named entity 'close' named entity 'machinery' named entity 'ABILITY TO' named entity 'HOST CELL' named entity 'LEVELS' named entity 'FUNCTIONS' named entity 'THERAPEUTICS' named entity 'NUCLEAR PORE COMPLEX' named entity 'STRUCTURES' named entity 'HOST CELL' named entity 'HAND' named entity 'REDISTRIBUTION' named entity 'THEIR' named entity 'INFECTION' named entity 'NS5A' named entity 'PROFOUND' named entity 'RNA AMPLIFICATION' named entity 'LOCALIZE' named entity 'CAUSES' named entity 'VIRUSES' named entity 'HCV' named entity 'NUCLEOPORINS' named entity 'MACHINERY' named entity 'SEQUENCE' named entity 'FACTORIES' named entity 'NUCLEOCYTOPLASMIC TRANSPORT' named entity 'PRODUCTIVE' named entity 'HCV INFECTION' named entity 'NOVEL' named entity 'VIRAL RNA' named entity 'INTERACTING' named entity 'CORE' named entity 'PROMOTE' named entity 'STUDIES' named entity 'SMALL' named entity 'TARGETS' named entity 'TO FORM' named entity 'POSSIBLE' named entity 'THE CELL' named entity 'WHERE' named entity 'FUNCTIONALITY' named entity 'SIGNALING' named entity 'INTERACT' named entity 'HEPATITIS C VIRUS' named entity 'THESE' named entity 'REPLICATING' named entity 'PROTEINS' named entity 'AFFECTING' named entity 'EXPRESSION' named entity 'INTERFERE' named entity 'APPARATUS' named entity 'EITHER' named entity 'PROCESSES' named entity 'BEARING' named entity 'ENDOPLASMIC RETICULUM MEMBRANE' named entity 'ENCODED' named entity 'DERIVED' named entity 'HEPATITIS C VIRUS' named entity 'NUCLEOPROTEINS' named entity 'CERTAIN' named entity 'COMPONENTS' named entity 'REVIEW' named entity 'MACHINERY' named entity 'HOST IMMUNE RESPONSE' named entity 'RECENT' named entity 'PATHOGENESIS' named entity 'CELL NUCLEUS' named entity 'MODULATING' named entity 'DIFFERENT' named entity 'NUCLEAR LOCALIZATION'

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