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About:
Seasonal and pandemic influenza during pregnancy and risk of fetal death: A Norwegian registry-based cohort study
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wasabi.inria.fr
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research paper
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Seasonal and pandemic influenza during pregnancy and risk of fetal death: A Norwegian registry-based cohort study
Creator
Bakken, Inger
Ghaderi, Sara
Gran, Jon
Gunnes, Nina
Samuelsen, Sven
Skrondal, Anders
Stoltenberg, Camilla
Trogstad, Lill
Wilcox, Allen
Håberg, Eldevik
Siri, ·
Gjessing, Kristian
Håkon, ·
Magnus, ·
Olav Hungnes, ·
source
PMC
abstract
Previous studies of fetal death with maternal influenza have been inconsistent. We explored the effect of maternal influenza-like illness (ILI) in pregnancy on the risk of fetal death, distinguishing between diagnoses during regular influenza seasons and the 2009/2010 pandemic and between trimesters of ILI. We used birth records from the Medical Birth Registry of Norway to identify fetal deaths after the first trimester in singleton pregnancies (2006–2013). The Norwegian Directorate of Health provided dates of clinical influenza diagnoses by primary-health-care providers, whereas dates of laboratory-confirmed influenza A (H1N1) diagnoses were provided by the Norwegian Surveillance System for Communicable Diseases. We obtained dates and types of influenza vaccinations from the Norwegian Immunisation Registry. Cox proportional-hazards regression models were fitted to estimate hazard ratios (HRs) of fetal death, with associated 95% confidence intervals (CIs), comparing women with and without an ILI diagnosis in pregnancy. There were 2510 fetal deaths among 417,406 eligible pregnancies. ILI during regular seasons was not associated with increased risk of fetal death: adjusted HR = 0.90 (95% CI 0.64–1.27). In contrast, ILI during the pandemic was associated with substantially increased risk of fetal death, with an adjusted HR of 1.75 (95% CI 1.21–2.54). The risk was highest following first-trimester ILI (adjusted HR = 2.28 [95% CI 1.45–3.59]). ILI during the pandemic—but not during regular seasons—was associated with increased risk of fetal death in the second and third trimester. The estimated effect was strongest with ILI in first trimester. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10654-020-00600-z) contains supplementary material, which is available to authorized users.
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2020-01-16
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bibo:doi
10.1007/s10654-020-00600-z
bibo:pmid
31950373
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cc-by
sha1sum (hex)
808a9006bbdd7cb9bd3955be0ac9f63c012b9649
schema:url
https://doi.org/10.1007/s10654-020-00600-z
resource representing a document's title
Seasonal and pandemic influenza during pregnancy and risk of fetal death: A Norwegian registry-based cohort study
has PubMed Central identifier
PMC7192880
has PubMed identifier
31950373
schema:publication
Eur J Epidemiol
resource representing a document's body
covid:808a9006bbdd7cb9bd3955be0ac9f63c012b9649#body_text
is
schema:about
of
named entity 'contrast'
named entity 'Surveillance'
named entity 'fetal'
named entity 'ILI'
named entity 'influenza-like illness'
named entity 'Health'
named entity 'H1N1'
named entity 'fetal death'
named entity 'dates'
named entity 'risk'
named entity 'ILI'
named entity 'Registry'
named entity 'risk'
named entity '2011'
named entity 'Seasonal'
named entity 'H1N1'
named entity 'Communicable Diseases'
named entity 'ILI'
named entity 'ILI'
named entity 'fetal'
named entity 'ILI'
named entity 'fetal death'
named entity 'ILI'
named entity 'regression models'
named entity 'pandemic influenza'
named entity 'fetal death'
named entity '95% CI'
named entity 'live births'
named entity 'R80'
named entity 'birth records'
named entity 'fetal death'
named entity 'swine flu'
named entity 'influenza epidemic'
named entity 'pandemic influenza'
named entity 'differential diagnoses'
named entity 'England'
named entity 'birth records'
named entity 'ILI'
named entity 'pregnancy'
named entity 'influenza'
named entity 'primary health care'
named entity 'pandemic influenza'
named entity 'Influenza vaccinations'
named entity 'chronic conditions'
named entity 'pregnancy'
named entity 'pregnancy'
named entity 'public-health'
named entity 'gestational week'
named entity 'pregnancy'
named entity 'influenza'
named entity 'swine flu'
named entity 'fetal death'
named entity 'thyroid disease'
named entity 'maternal antibodies'
named entity 'influenza'
named entity 'R80'
named entity 'chronic hypertension'
named entity 'A(H1N1)pdm09'
named entity 'Release 15'
named entity 'pregnancy'
named entity 'influenza'
named entity 'live birth'
named entity 'primary health care'
named entity 'vaccination'
named entity 'birth records'
named entity 'pregnancy'
named entity 'International Classification of Primary Care'
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