About: T cell-mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-γ

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: T cell-mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-γ Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	T cell-mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-γ
Creator	Hu, Shuxian Cheeran, Maxim C-J Gekker, Genya Lokensgard, James Palmquist, Joseph
Source	PMC
abstract	The authors have previously reported that adoptive transfer of splenocytes suppresses murine cytomegalovirus (MCMV) brain infection following intracerebroventricular injection of immunodeficient mice and that depletion of Thy 1.2(+) T lymphocytes abolishes this suppressive effect. Here the authors report that splenocytes depleted of CD4(+) T lymphocytes prior to adoptive transfer retained their ability to control viral expression in the brain. In sharp contrast, depletion of the CD8(+) T-cell population prior to transfer abolished the suppressive effect, with sixfold greater expression in the brain than when undepleted splenocytes were used. The authors went on to examine the contributions of cytokine- and perforin-mediated mechanisms in controlling MCMV brain infection using splenocytes from major histocompatibility (MHC)-matched IFN-γ-knockout (GKO), and perforin-knockout (PKO) mice. When used in adoptive transfer studies, splenocytes from GKO mice controlled viral expression; however, cells from PKO mice could not control reporter gene expression or viral DNA replication in brain tissues. The authors have previously reported that the levels of the T-cell chemoattractant CXCL10 are highly elevated in the brains of MCMV-infected mice. Here the authors found that the receptor for this ligand, CXCR3, was not essential in mediating the suppressive effects of adoptive transfer. These data indicate that peripheral CD8(+) T cells control MCMV brain infection through a perforin-mediated mechanism and that neither IFN-γ nor CXCR3 play a critical role in this neuroprotective response.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1080/13550280590952808
bibo:pmid	16036807
has license	no-cc
sha1sum (hex)	809a968cae0d7e599d45ddabc769dbd0054fabb2
schema:url	https://doi.org/10.1080/13550280590952808
resource representing a document's title	T cell-mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-γ
has PubMed Central identifier	PMC7095405
has PubMed identifier	16036807
schema:publication	J Neurovirol
resource representing a document's body	covid:809a968cae0d7e599d45ddabc769dbd0054fabb2#body_text
is schema:about of	named entity 'sharp' named entity 'viral' named entity 'authors' named entity 'mice' named entity 'When' named entity 'brain infection' named entity 'prior' named entity 'T-cell' named entity 'T lymphocytes' named entity 'mechanism' named entity 'infection' named entity 'cytomegalovirus' named entity 'cell-mediated' named entity 'DISPLAYS' named entity 'MURINE CYTOMEGALOVIRUS' named entity 'INFECTION' named entity 'SUPPRESSIVE EFFECT' named entity 'HISTOCOMPATIBILITY' named entity 'INFECTED' named entity 'SUPPRESSES' named entity 'REPORTER GENE' named entity 'AUTHORS' named entity 'HERE' covid:arg/809a968cae0d7e599d45ddabc769dbd0054fabb2 named entity 'CELLS' named entity 'LIGAND' named entity 'PERIPHERAL' named entity 'T CELLS' named entity 'CONTROLLED' named entity 'DEPLETION' named entity 'REPORT' named entity 'MECHANISM' named entity 'CONTROLLING' named entity 'SUPPRESSIVE' named entity 'MAJOR' named entity 'ESSENTIAL' named entity 'FOLLOWING' named entity 'RESTRICTION' named entity 'PERFORIN' named entity 'CD4' named entity 'DEPENDENCE' named entity 'MEDIATED' named entity 'INTERFERON' named entity 'DATA' named entity 'BUT' named entity 'T CELL' named entity 'PERFORIN' named entity 'T-CELL' named entity 'NEUROVIROLOGY' named entity 'RECEPTOR' named entity 'INJECTION' named entity 'IMMUNODEFICIENT' named entity 'REPORTED' named entity 'CYTOKINE' named entity 'EFFECTS' named entity 'EXPRESSION' named entity 'ADOPTIVE TRANSFER' named entity 'ROLE' named entity 'MCMV' named entity 'CXCR3' named entity 'BRAIN TISSUES' named entity 'TO TRANSFER' named entity 'USED' named entity 'CXCL10' named entity 'CHEMOATTRACTANT' named entity 'BRAIN' named entity 'RETAINED' named entity 'CONTROL' named entity 'HAVE' named entity '1.2' named entity 'GREATER' named entity 'MURINE CYTOMEGALOVIRUS' named entity 'INTRACEREBRAL' named entity 'MATCHED' named entity 'CELL POPULATION' named entity 'THY' named entity 'KNOCKOUT'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software