About: A Rabbit Model of Hormone-induced Early Avascular Necrosis of the Femoral Head

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About: A Rabbit Model of Hormone-induced Early Avascular Necrosis of the Femoral Head Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Rabbit Model of Hormone-induced Early Avascular Necrosis of the Femoral Head
Creator	Yang, Lin Chen, Yan-Ping Luo #, Wei Ma #, L Qian, Wen Wang, Xiao-Ning
Source	Elsevier; Medline; PMC
abstract	Abstract Objective To establish an experimental model of early stage avascular necrosis of the femoral head (ANFH) caused by corticosteroid in adult rabbits and to observe the pathological changes with various imaging techniques. Methods ANFH was induced by a combination of hypersensitivity vasculitis caused by injection of horse serum and subsequent administration of a high dose of corticosteroid. The pathological changes were detected with digital radiography (DR), computed tomography (CT), magnetic resonance imaging (MRI), ink artery infusion angiography, hematoxylin–eosin staining, and immunohistochemistry. Results The imageological and pathological changes corresponded to the clinical characteristics of early stage ANFH. DR showed bilaterally increased bone density, an unclear epiphyseal line, and blurred texture of cancellous bone. CT showed spot-like low-density imaging of cancellous bone, thinner cortical bone, osteoporosis, and an unclear epiphyseal line. MRI showed bone marrow edema and spot-like high signals in T2-weighted imaging in cancellous bone. Ink artery infusion angiography showed fewer obstructed blood vessels in the femoral head. HE staining of pathological sections showed fewer trabeculae and thin bone, an increased proportion of empty osteocyte lacunae, decreased hematopoiesis, thrombosis, and fat cell hypertrophy. Immunohistochemistry showed attenuated expression of vascular endothelial growth factor in osteoblasts and chondrocytes, and on the inner membrane of blood vessels. Conclusion Experimental rabbit model of early stage ANFH caused by corticosteroid can be successfully established and provide the foundation for developing effective methods to treat early stage ANFH.
has issue date	2008-10-31(xsd:dateTime)
bibo:doi	10.1016/s0895-3988(08)60060-4
bibo:pmid	19133613
has license	els-covid
sha1sum (hex)	80ddfdb396529de0a944b29264f6475ab0930224
schema:url	https://doi.org/10.1016/s0895-3988%2808%2960060-4
resource representing a document's title	A Rabbit Model of Hormone-induced Early Avascular Necrosis of the Femoral Head
has PubMed Central identifier	PMC7134729
has PubMed identifier	19133613
schema:publication	Biomedical and Environmental Sciences
resource representing a document's body	covid:80ddfdb396529de0a944b29264f6475ab0930224#body_text
is schema:about of	named entity 'staining' named entity 'cancellous bone' named entity 'imaging' named entity 'serum' named entity 'injection' named entity 'HORMONE' named entity 'MODEL OF' named entity 'DIGITAL RADIOGRAPHY' named entity 'EXPRESSION' named entity 'RABBIT MODEL' named entity 'ESTABLISH' named entity 'CANCELLOUS BONE' named entity 'AVASCULAR NECROSIS OF THE FEMORAL HEAD' named entity 'SIGNALS' named entity 'LACUNAE' named entity 'INCREASED BONE DENSITY' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'LIKE' named entity 'TREAT' named entity 'EXPERIMENTAL' named entity 'OSTEOBLASTS' named entity 'BILATERALLY' named entity 'METHODS' named entity 'HYPERSENSITIVITY VASCULITIS' named entity 'FEMORAL HEAD' named entity 'THINNER' named entity 'RABBIT MODEL' named entity 'CORTICOSTEROID' named entity 'ANGIOGRAPHY' named entity 'ATTENUATED' named entity 'UNCLEAR' named entity 'TO OBSERVE' named entity 'DETECTED' named entity 'EXPERIMENTAL MODEL' named entity 'CHONDROCYTES' named entity 'RESULTS' named entity 'ADULT' named entity 'LOW-DENSITY' named entity 'SUBSEQUENT' named entity 'TRABECULAE' named entity 'STAINING' named entity 'IMAGING TECHNIQUES' named entity 'AVASCULAR NECROSIS OF THE FEMORAL HEAD' named entity 'EARLY' named entity 'CHANGES' named entity 'ESTABLISHED' named entity 'HIGH DOSE' named entity 'HIGH' named entity 'HEMATOXYLIN' named entity 'DECREASED HEMATOPOIESIS' named entity 'CORTICAL BONE' named entity 'SPOT' named entity 'VASCULAR ENDOTHELIAL GROWTH FACTOR' named entity 'PROVIDE' named entity 'INDUCED' named entity 'MODEL OF' named entity 'CAUSED BY' named entity 'EPIPHYSEAL LINE' named entity 'EOSIN' named entity 'IMAGING' named entity 'COMBINATION' named entity 'COMPUTED TOMOGRAPHY' named entity 'PATHOLOGICAL' named entity 'MRI' named entity 'HORSE SERUM' named entity 'BY INJECTION' named entity 'THROMBOSIS' named entity 'ANFH' named entity 'OSTEOCYTE' named entity 'EARLY STAGE' named entity 'CLINICAL CHARACTERISTICS' named entity 'VARIOUS' named entity 'INNER MEMBRANE' named entity 'FAT CELL HYPERTROPHY' named entity 'TEXTURE' named entity 'BLOOD VESSELS'

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