About: Ubiquitin-Specific Proteases 25 Negatively Regulates Virus-Induced Type I Interferon Signaling

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ubiquitin-Specific Proteases 25 Negatively Regulates Virus-Induced Type I Interferon Signaling
Creator	Wang, D Zhang, H Luo, R Fang, L Zhong, H
Source	PMC
abstract	Ubiquitination and deubiquitination have emerged as critical regulatory processes in the virus-triggered type I interferon (IFN) induction pathway. In this study, we carried out a targeted siRNA screen of 54 ubiquitin-specific proteases (USPs) and identified USP25 as a negative regulator of the virus-triggered type I IFN signaling pathway. Overexpression of USP25 inhibited virus-induced activation of IFN-β, interferon regulation factor 3 (IRF3) and nuclear factor-kappa B (NF-κB), as well as the phosphorylation of IRF3 and NF-κB subunit p65. Furthermore, Knockdown of USP25 potentiated virus-induced induction of the IFN-β. In addition, detailed analysis demonstrated that USP25 cleaved lysine 48- and lysine 63-linked polyubiquitin chains in vitro and in vivo, and its deubiquitinating enzyme (DUB) activity, were dependent on a cysteine residue (Cys178) and a histidine residue (His607). USP25 mutants lacking DUB activity lost the ability to block virus-induced type I IFN to some degree. Mechanistically, USP25 deubiquitinated retinoic acid-inducible gene I (RIG-I), tumornecrosis factor (TNF) receptor-associated factor 2 (TRAF2), and TRAF6 to inhibit RIG-I-like receptor-mediated IFN signaling. Our findings suggest that USP25 is a novel DUB negatively regulating virus-induced type I IFN production.
has issue date	2013-11-18(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0080976
bibo:pmid	24260525
has license	cc-by
sha1sum (hex)	810749401200c77f19d5a7950070e0c2d4d2629e
schema:url	https://doi.org/10.1371/journal.pone.0080976
resource representing a document's title	Ubiquitin-Specific Proteases 25 Negatively Regulates Virus-Induced Type I Interferon Signaling
has PubMed Central identifier	PMC3832446
has PubMed identifier	24260525
schema:publication	PLoS One
resource representing a document's body	covid:810749401200c77f19d5a7950070e0c2d4d2629e#body_text
is schema:about of	named entity 'BAB' named entity 'RECEPTOR' named entity 'IN VITRO' named entity 'LIKE' named entity 'PROCESSES' named entity 'MEDIATED' named entity 'TARGETED' named entity 'CHAINS' named entity 'TRIGGERED' named entity 'RIG-I' named entity 'SIGNALING' named entity 'DEGREE' named entity 'TYPE I IFN PRODUCTION' named entity 'DEUBIQUITINATION' named entity 'INHIBITED' named entity 'ASSOCIATED' named entity 'ANALYSIS' named entity 'VIRUS' named entity 'UBIQUITINATION' named entity 'TRAF6' named entity 'ACTIVITY' named entity 'TYPE I' named entity 'HISTIDINE RESIDUE' named entity 'P65' named entity 'VIRUS' named entity 'signaling pathway' named entity 'siRNA' named entity 'deubiquitinating enzyme' named entity 'processes' named entity 'residue' named entity 'OVEREXPRESSION' named entity 'SUBUNIT' named entity 'SUGGEST' named entity 'MUTANTS' named entity 'ITS' named entity 'DETAILED' named entity 'ACTIVATION' named entity 'NOVEL' named entity 'UBIQUITIN-SPECIFIC PROTEASES' named entity 'ADDITION' named entity 'LACKING' named entity 'NEGATIVE REGULATOR' named entity 'POLYUBIQUITIN' named entity 'OUR' named entity 'TO INHIBIT' named entity 'NUCLEAR FACTOR-KAPPA B' named entity 'USP25' named entity 'IFN' named entity 'LYSINE' named entity 'RETINOIC ACID' named entity 'DUB' named entity 'REGULATING' named entity 'SIRNA' named entity 'INDUCED' named entity 'TYPE I INTERFERON' named entity 'CLEAVED' named entity 'FACTOR' named entity 'IN VIVO' named entity 'INDUCED' named entity 'HAVE' named entity 'IRF3' named entity 'INTERFERON ' named entity 'PHOSPHORYLATION' named entity 'LOST' named entity 'DEPENDENT' named entity 'TYPE I INTERFERON' named entity 'CARRIED' named entity 'GENE' named entity 'IDENTIFIED' named entity 'UBIQUITIN-SPECIFIC PROTEASES' named entity 'INTERFERON SIGNALING' named entity 'CRITICAL' named entity 'FINDINGS' named entity 'SCREEN' named entity 'REGULATORY' named entity 'STUDY' named entity 'CYSTEINE RESIDUE'

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