About: Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus

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About: Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus
Creator	Barber, Matthew Buechi, Hanna Choby, Jacob Farrand, Allison Skaar, Eric Kline, Kimberly
Source	PMC
abstract	Metals are a limiting resource for pathogenic bacteria and must be scavenged from host proteins. Hemoglobin provides the most abundant source of iron in the human body and is required by several pathogens to cause invasive disease. However, the consequences of hemoglobin evolution for bacterial nutrient acquisition remain unclear. Here we show that the α- and β-globin genes exhibit strikingly parallel signatures of adaptive evolution across simian primates. Rapidly evolving sites in hemoglobin correspond to binding interfaces of IsdB, a bacterial hemoglobin receptor harbored by pathogenic Staphylococcus aureus. Using an evolution-guided experimental approach, we demonstrate that the divergence between primates and staphylococcal isolates governs hemoglobin recognition and bacterial growth. The reintroduction of putative adaptive mutations in α- or β-globin proteins was sufficient to impair S. aureus binding, providing a mechanism for the evolution of disease resistance. These findings suggest that bacterial hemoprotein capture has driven repeated evolutionary conflicts with hemoglobin during primate descent.
has issue date	2018-11-20(xsd:dateTime)
bibo:doi	10.1128/mbio.01524-18
bibo:pmid	30459189
has license	cc-by
sha1sum (hex)	8125e22d2dc5ad5fe51394fc08dc89212c833d2c
schema:url	https://doi.org/10.1128/mbio.01524-18
resource representing a document's title	Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus
has PubMed Central identifier	PMC6247092
has PubMed identifier	30459189
schema:publication	mBio
resource representing a document's body	covid:8125e22d2dc5ad5fe51394fc08dc89212c833d2c#body_text
is schema:about of	named entity 'RESOURCE' named entity 'HAVE' named entity 'HEMOPROTEIN' named entity 'MECHANISM' named entity 'SUFFICIENT' named entity 'DISEASE RESISTANCE' named entity 'SIMIAN' named entity 'IRON' named entity 'INTERFACE' named entity 'BACTERIAL GROWTH' named entity 'BACTERIA ' named entity 'NUTRIENT ACQUISITION' named entity 'PROVIDING' named entity 'HEMOGLOBIN' named entity 'OVERCOME' named entity 'A HEMOGLOBIN' named entity 'EXPERIMENTAL' named entity 'PARALLEL' named entity 'SUGGEST' named entity 'PROVIDES' named entity 'CAUSE' named entity 'CONSEQUENCES' named entity 'PROCESSES' named entity 'EVOLVING' named entity 'ACROSS' named entity 'PROTEINS' named entity 'host' named entity 'staphylococcal' named entity 'interface' named entity 'pathogenic' named entity 'binding' named entity 'metal' named entity 'METAL' named entity 'PRIMATE' named entity 'METALS' named entity 'UNCLEAR' named entity '90%' named entity 'HEME' named entity 'FINDINGS' named entity 'ISDB' named entity 'USES' named entity 'S. AUREUS' named entity 'PROTEIN SURFACES' named entity 'TISSUE' named entity 'BINDING' named entity 'STEAL' named entity 'HUMAN BODY' named entity 'REPEATED' named entity 'GLOBIN GENES' named entity 'DRIVEN' named entity 'BATTLE' named entity 'REINTRODUCTION' named entity 'BACTERIAL' named entity 'ACQUISITION' covid:arg/8125e22d2dc5ad5fe51394fc08dc89212c833d2c named entity 'SPECIES' named entity 'EVOLUTION' named entity 'MOLECULAR BASIS' named entity 'HEMOGLOBIN' named entity 'SPECIFIC' named entity 'RAPID EVOLUTION' named entity 'SEQUENCES' named entity 'HOST' named entity 'STAPHYLOCOCCUS AUREUS' named entity 'MUTATIONS' named entity 'PRIMATES' named entity 'GLOBIN' named entity 'SIGNATURES' named entity 'PATHOGENS' named entity 'BACTERIAL HEMOGLOBIN' named entity 'RECOGNIZE' named entity 'APPROACH' named entity 'FACE' named entity 'VARIATION' named entity 'PATHOGENIC BACTERIA' named entity 'DESCENT'

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