About: Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

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About: Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein
Creator	Baric, Ralph Wang, Nianshuang Wrapp, Daniel Chandran, Kartik Brown, Michael Hsieh, Ching-Lin Dye, John Burton, Dennis Graham, Barney Herbert, Andrew Jangra, Rohit Johnson, Carl Mclellan, Jason Wec, Anna Wirchnianski, Ariel Walker, Laura Nemazee, David Burnina, Irina Champney, Elizabeth Dieterle, M Fels, J Florez, Catalina Haslwanter, Denise Huang, Deli Iii, Robert Johnson, Nicole Laudermilch, Ethan Lilov, Asparouh Lin, Shu Maurer, Daniel Nett, Juergen O'brien, Cecilia Pudi, Sarat Sakharkar, Mrunal Sinclair, Melanie Tse, Longping Voss, James
Source	BioRxiv; Medline; PMC
abstract	Broadly protective vaccines against known and pre-emergent coronaviruses are urgently needed. Critical to their development is a deeper understanding of cross-neutralizing antibody responses induced by natural human coronavirus (HCoV) infections. Here, we mined the memory B cell repertoire of a convalescent SARS donor and identified 200 SARS-CoV-2 binding antibodies that target multiple conserved sites on the spike (S) protein. A large proportion of the antibodies display high levels of somatic hypermutation and cross-react with circulating HCoVs, suggesting recall of pre-existing memory B cells (MBCs) elicited by prior HCoV infections. Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the bat SARS-like virus WIV1 by blocking receptor attachment and inducing S1 shedding. These antibodies represent promising candidates for therapeutic intervention and reveal a new target for the rational design of pan-sarbecovirus vaccines.
has issue date	2020-05-16(xsd:dateTime)
bibo:doi	10.1101/2020.05.15.096511
bibo:pmid	32511337
has license	cc-by-nc-nd
sha1sum (hex)	81391284a0d4cddf57c77b64126b1174f17cb420
schema:url	https://doi.org/10.1101/2020.05.15.096511
resource representing a document's title	Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein
has PubMed Central identifier	PMC7241100
has PubMed identifier	32511337
schema:publication	bioRxiv
resource representing a document's body	covid:81391284a0d4cddf57c77b64126b1174f17cb420#body_text
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