About: The CD200–CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host

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About: The CD200–CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host–Pathogen Interactions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The CD200–CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host–Pathogen Interactions
Creator	Soberman, Roy Vaine, Christine
Source	Elsevier; Medline; PMC
abstract	The CD200:CD200R1 inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. CD200R1 signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to selected stimuli. Unsurprisingly, due to the regulatory role that CD200R1 plays in multiple inflammatory pathways, an increasing number of parasitic, bacterial, and viral pathogens exploit this pathway to suppress host defenses. A complete understanding of the pathways regulated by CD200R1 signaling and the diverse mechanisms that pathogens have evolved to manipulate the CD200:CD200R1 pathway can help identify clinical situations where targeting this interaction can be of therapeutic benefit. In this review, we compare CD200R1 to other pathogen-targeted inhibitory receptors and highlight how this signaling pathway is utilized by a diverse number of pathogens and, therefore, may represent a novel targeting strategy for the treatment of infectious diseases.
has issue date	2014-01-01(xsd:dateTime)
bibo:doi	10.1016/b978-0-12-800100-4.00005-2
bibo:pmid	24388216
has license	green-oa
sha1sum (hex)	81af605faf3fcd177c45e82efadb87cf82c02917
schema:url	https://doi.org/10.1016/b978-0-12-800100-4.00005-2
resource representing a document's title	The CD200–CD200R1 Inhibitory Signaling Pathway: Immune Regulation and Host–Pathogen Interactions
has PubMed Central identifier	PMC4617684
has PubMed identifier	24388216
schema:publication	Advances in Immunology
resource representing a document's body	covid:81af605faf3fcd177c45e82efadb87cf82c02917#body_text
is schema:about of	named entity 'SIGNALING PATHWAY' named entity 'CD200' named entity 'HOST-PATHOGEN INTERACTIONS' named entity 'REGULATION' named entity 'CD200R1' named entity 'IMMUNE' named entity 'INHIBITORY' named entity 'Immune Regulation' named entity 'Host-Pathogen Interactions' named entity 'positively charged' named entity 'mice' named entity 'serum' named entity 'endothelial cells' named entity 'macrophage' named entity 'CD200R1' named entity 'CD200R1' named entity 'proinflammatory cytokine' named entity 'inflammatory response' named entity 'CD200R1' named entity 'coreceptor' named entity 'blood vessel' named entity 'TNFa' named entity 'cell types' named entity 'CD200' named entity 'HCMV' named entity 'macrophages' named entity 'F4/80' named entity 'HSV-1' named entity 'macrophages' named entity 'ligand' named entity 'N. meningitidis' named entity 'CD200' named entity 'KO mice' named entity 'significant difference' named entity 'CD200R1' named entity 'HLA-E' named entity 'downregulation' named entity 'CD200R1' named entity 'ROS' named entity 'leukocyte' named entity 'orthologs' named entity 'phosphorylation' named entity 'bacteremia' named entity 'oligomerization' named entity 'model systems' named entity 'CD200' named entity 'superinfection' named entity 'iNOS' named entity 'parasite' named entity 'S. pneumoniae' named entity 'Pathogens' named entity 'MHC class II' named entity 'replication and development' named entity 'influenza infection' named entity 'KO mice' named entity 'CD94/NKG2' named entity 'NK cells' named entity 'N-terminal region' named entity 'viral titers' named entity 'KO mice' named entity 'CD200' named entity 'IFN' named entity 'inflammatory responses' named entity 'TLR' named entity 'NK cell' named entity 'mRNA' named entity 'antigens' named entity 'viral titers' named entity 'HCMV' named entity 'ligand' named entity 'Caserta' named entity 'exosomes' named entity 'protein' named entity 'immunoreceptor' named entity 'macrophages' named entity 'MCMV' named entity 'CD200R1' named entity 'human herpesvirus 8' named entity 'S. aureus' named entity 'HSV-1 infection'

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