About: Genetically delivered antibody protects against West Nile virus

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About: Genetically delivered antibody protects against West Nile virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetically delivered antibody protects against West Nile virus
Creator	Borisevich, Viktoriya Hudman, Deborah Kazachinskaia, Elena Loktev, Valery Pereboev, Alexander Razumov, Ivan Shakhmatov, Mikhail Svyatchenko, Viktor Tsuladze, George Yamshchikov, Vladimir
Source	Elsevier; Medline; PMC
abstract	Gene-based delivery of recombinant antibody genes is a promising therapeutic strategy offering numerous advantages including sustained antibody levels, better safety profile and lower production cost. Here we describe generation of a recombinant antibody Fc-9E2 comprising a fusion protein between human Fc of IgG1 and a single-chain Fv derived from a hybridoma 9E2 secreting a mAb neutralizing West Nile virus (WNV). Fc-9E2 was shown to retain parental mAb's specificity and WNV-neutralizing capacity. Adenovirus-mediated in vivo delivery of the antibody gene resulted in sustained Fc-9E2 serum levels leading to abrogation of lethal WNV infection in an animal model.
has issue date	2008-01-01(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2007.08.010
bibo:pmid	17904654
has license	green-oa
sha1sum (hex)	81b4acc255fe9b2da57588648252e9169d07f0df
schema:url	https://doi.org/10.1016/j.antiviral.2007.08.010
resource representing a document's title	Genetically delivered antibody protects against West Nile virus
has PubMed Central identifier	PMC2267767
has PubMed identifier	17904654
schema:publication	Antiviral Research
resource representing a document's body	covid:81b4acc255fe9b2da57588648252e9169d07f0df#body_text
is schema:about of	named entity 'DELIVERED' named entity 'WEST NILE VIRUS' named entity 'hybridoma' named entity 'numerous' named entity 'serum' named entity 'derived' covid:arg/81b4acc255fe9b2da57588648252e9169d07f0df named entity 'IGG1' named entity 'DESCRIBE' named entity 'RECOMBINANT ANTIBODY' named entity 'LEADING' named entity 'HERE' named entity 'GENES' named entity 'ANIMAL MODEL' named entity 'PARENTAL' named entity 'GENERATION' named entity 'SPECIFICITY' named entity 'GENE' named entity 'RETAIN' named entity 'HUMAN' named entity 'LETHAL' named entity 'SINGLE-CHAIN FV' named entity 'ADENOVIRUS' named entity 'STRATEGY' named entity 'LOWER' named entity '27S' named entity 'WEST NILE VIRUS' named entity 'ANTIBODY' named entity 'LEVELS' named entity 'IS A' named entity 'COST' named entity 'PROTEIN ' named entity 'FUSION PROTEIN' named entity 'SUSTAINED' named entity 'CAPACITY' named entity 'ANTIBODY' named entity 'WNV INFECTION' named entity 'DERIVED' named entity 'BETTER' named entity 'BASED' named entity 'THERAPEUTIC' named entity 'SERUM' named entity 'MAB' named entity 'IN VIVO' named entity 'OFFERING' named entity 'SAFETY' named entity 'NUMEROUS' named entity 'HYBRIDOMA' named entity 'INCLUDING' named entity 'MEDIATED' named entity 'DELIVERY' named entity 'PRODUCTION' named entity 'PROFILE' named entity 'SECRETING' named entity 'West Nile virus' named entity 'strategy' named entity 'genes' named entity 'recombinant' named entity 'advantages' named entity 'infection' named entity 'generation' named entity 'mAb' named entity 'safety profile' named entity 'hybridoma' named entity 'gene' named entity 'West Nile virus' named entity 'antibody' named entity 'recombinant antibody' named entity 'antibody' named entity 'cost' named entity 'kDa' named entity 'polyadenylation signal'

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