About: G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

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About: G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
Creator	Ruggiero, Emanuela Richter, Sara
Source	Medline; PMC
abstract	G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in recent years the presence of G4s in viruses has attracted increasing interest. Indeed, G4s have been reported in several viruses, including those involved in recent epidemics, such as the Zika and Ebola viruses. Viral G4s are usually located in regulatory regions of the genome and implicated in the control of key viral processes; in some cases, they have been involved also in viral latency. In this context, G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle, and as therapeutic agents. In general, G4 ligands showed promising antiviral activity, with G4-mediated mechanisms of action both at the genome and transcript level. This review aims to provide an updated close-up of the literature on G4s in viruses. The current state of the art of G4 ligands in antiviral research is also reported, with particular focus on the structural and physicochemical requirements for optimal biological activity. The achievements and the to-dos in the field are discussed.
has issue date	2018-04-20(xsd:dateTime)
bibo:doi	10.1093/nar/gky187
bibo:pmid	29554280
has license	cc-by
sha1sum (hex)	81b992164d368b01c45fa3cc4ffd54d525e1d4b2
schema:url	https://doi.org/10.1093/nar/gky187
resource representing a document's title	G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
has PubMed Central identifier	PMC5909458
has PubMed identifier	29554280
schema:publication	Nucleic Acids Res
resource representing a document's body	covid:81b992164d368b01c45fa3cc4ffd54d525e1d4b2#body_text
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