About: Beyond Channel Activity: Protein-Protein Interactions Involving Viroporins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Beyond Channel Activity: Protein-Protein Interactions Involving Viroporins
Creator	Torres, Jaume To, Janet
source	Medline; PMC
abstract	Viroporins are short polypeptides encoded by viruses. These small membrane proteins assemble into oligomers that can permeabilize cellular lipid bilayers, disrupting the physiology of the host to the advantage of the virus. Consequently, efforts during the last few decades have been focused towards the discovery of viroporin channel inhibitors, but in general these have not been successful to produce licensed drugs. Viroporins are also involved in viral pathogenesis by engaging in critical interactions with viral proteins, or disrupting normal host cellular pathways through coordinated interactions with host proteins. These protein-protein interactions (PPIs) may become alternative attractive drug targets for the development of antivirals. In this sense, while thus far most antiviral molecules have targeted viral proteins, focus is moving towards targeting host proteins that are essential for virus replication. In principle, this largely would overcome the problem of resistance, with the possibility of using repositioned existing drugs. The precise role of these PPIs, their strain- and host- specificities, and the structural determination of the complexes involved, are areas that will keep the fields of virology and structural biology occupied for years to come. In the present review, we provide an update of the efforts in the characterization of the main PPIs for most viroporins, as well as the role of viroporins in these PPIs interactions.
has issue date	2018-06-14(xsd:dateTime)
bibo:doi	10.1007/978-981-10-8456-0_15
bibo:pmid	29900504
has license	no-cc
sha1sum (hex)	81e6258bfab027095b794bbeaf024687ee771236
schema:url	https://doi.org/10.1007/978-981-10-8456-0_15
resource representing a document's title	Beyond Channel Activity: Protein-Protein Interactions Involving Viroporins
has PubMed Central identifier	PMC7122450
has PubMed identifier	29900504
schema:publication	Virus Protein and Nucleoprotein Complexes
resource representing a document's body	covid:81e6258bfab027095b794bbeaf024687ee771236#body_text
is schema:about of	named entity 'Activity' named entity 'BEYOND' named entity 'INVOLVING' named entity 'INHIBITION' named entity 'CHANNEL ACTIVITY' named entity 'PROTEIN-PROTEIN INTERACTIONS' named entity 'Channel' named entity 'Golgi' named entity 'antigen' named entity 'structural genes' named entity 'NMR' named entity 'functional domains' named entity 'NSP4' named entity 'protein' named entity 'Hepatitis' named entity 'ATPase' named entity 'protein' named entity 'yeast-two-hybrid' named entity 'anti-parallel' named entity 'NSP4' named entity 'host defense' named entity 'NS2' named entity 'NS5A' named entity 'pro-apoptotic' named entity 'ion' named entity 'NS2' named entity 'actin' named entity 'Vpu' named entity 'protein' named entity 'plasma membrane' named entity 'inflammasome' named entity 'proteome' named entity 'nuclear export' named entity 'high-throughput technologies' named entity 'cytoplasmic' named entity 'nucleus' named entity 'motif' named entity 'cell surface' named entity 'immunomodulatory' named entity 'transfected' named entity 'NSP4' named entity 'error-prone' named entity 'endothelial' named entity 'phospholipid' named entity 'AnxA6' named entity 'M1 protein' named entity 'cell membrane' named entity 'NS2' named entity 'membrane proteins' named entity 'virion particles' named entity 'mitogen-activated protein kinase' named entity '215,000' named entity 'membrane curvature' named entity 'protein' named entity 'physical interaction' named entity 'C-terminal' named entity 'mutagenesis' named entity 'single-stranded' named entity 'virion' named entity 'SNAREs' named entity 'membrane proteins' named entity 'transfection' named entity 'amphipathic' named entity 'Coronaviridae' named entity 'infection' named entity 'virion' named entity 'binding activity' named entity 'MHC-I' named entity 'protein' named entity 'HCV' named entity 'cytosolic' named entity 'inflammasome' named entity 'proteomes' named entity 'cytoplasmic' named entity 'cyclin D3' named entity 'regulatory genes' named entity 'VP6' named entity 'Golgi' named entity 'ubiquitination' named entity 'IAV'

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