About: Molecular characterization of two novel reoviruses isolated from Muscovy ducklings in Guangdong, China

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About: Molecular characterization of two novel reoviruses isolated from Muscovy ducklings in Guangdong, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular characterization of two novel reoviruses isolated from Muscovy ducklings in Guangdong, China
Creator	Chi, Shi-Hong Guo, Jin-Yue Huang, Shu-Jian Huang, Wen-Jing Li, Wen-Feng Li, Xiao-Wen Li, Zhi-Li Mei, Min-Min Shao, Jian-Wei Yuan, Sheng Zhang, Xue-Lian
Source	Medline; PMC
abstract	BACKGROUND: Novel Muscovy duck reovirus (N-MDRV), emerged in southeast China in 2002, which can infect a wide range of waterfowl and induces clinical signs and cytopathic effects that are distinct from those of classical MDRV, and continues to cause high morbidity and 5–50% mortality in ducklings. The present study aimed to investigate the characteristics of two novel reoviruses isolated from Muscovy ducklings in Guangdong, China. RESULTS: Two novel MDRV strains, designated as MDRV-SH12 and MDRV-DH13, were isolated from two diseased Muscovy ducklings in Guangdong province, China in June 2012 and September 2013, respectively. Sequencing of the complete genomes of these two viruses showed that they consisted of 23,418 bp and were divided into 10 segments, ranging from 1191 bp (S4) to 3959 bp (L1) in length, and all segments contained conserved sequences in the 5′ non-coding region (GCUUUU) and 3′ non-coding region (UCAUC). Pairwise sequence comparisons demonstrated that MDRV-SH12 and MDRV-DH13 showed the highest similarity with novel MDRVs. Phylogenetic analyses of the nucleotide sequences of all 10 segments revealed that MDRV-SH12 and MDRV-DH13 were clustered together with other novel waterfowl-origin reoviruses and were distinct from classical waterfowl-origin and chicken-origin reoviruses. The analyses also showed possible genetic re-assortment events in segment M2 between waterfowl-origin and chicken-origin reoviruses and the segments encoding λA, μA, μNS, σA, and σNS between classical and novel waterfowl-origin reoviruses. Potential recombination events detection in segment S2 suggests that MDRV-SH12 and MDRV-DH13 may be recombinants of classical and novel WRVs. CONCLUSIONS: The results presented in this study, the full genomic data for two novel MDRV strains, will improve our understanding of the evolutionary relationships among the waterfowl-origin reoviruses circulating in China, and may aid in the development of more effective vaccines against various waterfowl-origin reoviruses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-019-1877-x) contains supplementary material, which is available to authorized users.
has issue date	2019-05-10(xsd:dateTime)
bibo:doi	10.1186/s12917-019-1877-x
bibo:pmid	31077188
has license	cc-by
sha1sum (hex)	82114e8ec9b0ac800be54578d1fd23d945209f12
schema:url	https://doi.org/10.1186/s12917-019-1877-x
resource representing a document's title	Molecular characterization of two novel reoviruses isolated from Muscovy ducklings in Guangdong, China
has PubMed Central identifier	PMC6511161
has PubMed identifier	31077188
schema:publication	BMC Vet Res
resource representing a document's body	covid:82114e8ec9b0ac800be54578d1fd23d945209f12#body_text
is schema:about of	named entity 'WIDE' named entity 'DISTINCT FROM' named entity 'INFECT' named entity 'SOUTHEAST' named entity 'NOVEL' named entity 'MOLECULAR' covid:arg/82114e8ec9b0ac800be54578d1fd23d945209f12 named entity 'BACKGROUND' named entity 'WATERFOWL' named entity 'STUDY' named entity 'TO INVESTIGATE' named entity 'HIGH' named entity 'REOVIRUS' named entity 'CLASSICAL' named entity 'NOVEL' named entity 'ISOLATED' named entity 'MUSCOVY' named entity 'REOVIRUSES' named entity 'MUSCOVY DUCK' named entity 'MORTALITY' named entity 'CYTOPATHIC EFFECTS' named entity 'CHINA' named entity 'CHARACTERIZATION' named entity 'MDRV' named entity 'PRESENT' named entity 'REOVIRUSES' named entity 'CHARACTERISTICS' named entity 'CHINA' named entity 'CAUSE' named entity '50%' named entity 'MORBIDITY' named entity 'RANGE' named entity 'MUSCOVY' named entity 'ISOLATED' named entity 'waterfowl' named entity 'Guangdong' named entity 'reovirus' named entity 'reoviruses' named entity 'nucleotide' named entity 'viruses' named entity 'evolution' named entity 'viruses' named entity 'ARVs' named entity 'viruses' named entity 'Sanger sequencing' named entity 'infection' named entity 'WRV' named entity 'monophyletic' named entity 'viruses' named entity 'ARVs' named entity 'reoviruses' named entity 'Avian orthoreovirus' named entity 'WRVs' named entity 'genome' named entity 'ARVs' named entity 'RT-PCR' named entity 'nucleotide sequences' named entity 'polycistronic' named entity 'WRVs' named entity 'phylogenetic trees' named entity 'ARVs' named entity 'viruses' named entity 'phylogenetic analyses' named entity 'WRVs' named entity 'China' named entity 'pericarditis' named entity 'liver' named entity 'viruses' named entity 'genome' named entity 'liver' named entity 'WRVs'

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