About: MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

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About: MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
Creator	Munster, Vincent Baric, Ralph Gralinski, Lisa Webb-Robertson, Bobbie-Jo Schäfer, Alexandra Sims, Amy Kawaoka, Yoshihiro Smith, Richard Hogue, Brenda Menachery, Vineet Mitchell, Hugh Bergmann, Cornelia Burnum-Johnson, Kristin Casey, Cameron Eisfeld, Amie Metz, Thomas Monroe, Matthew Nicora, Carrie Purvine, Samuel Stratton, Kelly Walters, Kevin Waters, Katrina Weitz, Karl
Source	Medline; PMC
abstract	Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems-based approach, we examined differential regulation of IFN-γ–dependent genes following infection with robust respiratory viruses including influenza viruses [A/influenza/Vietnam/1203/2004 (H5N1-VN1203) and A/influenza/California/04/2009 (H1N1-CA04)] and coronaviruses [severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV)]. Categorizing by function, we observed down-regulation of gene expression associated with antigen presentation following both H5N1-VN1203 and MERS-CoV infection. Further examination revealed global down-regulation of antigen-presentation gene expression, which was confirmed by proteomics for both H5N1-VN1203 and MERS-CoV infection. Importantly, epigenetic analysis suggested that DNA methylation, rather than histone modification, plays a crucial role in MERS-CoV–mediated antagonism of antigen-presentation gene expression; in contrast, H5N1-VN1203 likely utilizes a combination of epigenetic mechanisms to target antigen presentation. Together, the results indicate a common mechanism utilized by H5N1-VN1203 and MERS-CoV to modulate antigen presentation and the host adaptive immune response.
has issue date	2018-01-30(xsd:dateTime)
bibo:doi	10.1073/pnas.1706928115
bibo:pmid	29339515
has license	cc-by-nc-nd
sha1sum (hex)	82256b182006e2f9abcd1475c906b290a8daad13
schema:url	https://doi.org/10.1073/pnas.1706928115
resource representing a document's title	MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
has PubMed Central identifier	PMC5798318
has PubMed identifier	29339515
schema:publication	Proc Natl Acad Sci U S A
resource representing a document's body	covid:82256b182006e2f9abcd1475c906b290a8daad13#body_text
is schema:about of	named entity 'virus' named entity 'influenza virus' named entity 'epigenetic' named entity 'transcriptional factor' named entity 'epithelial cell' named entity 'Microarray' named entity 'histone modification' named entity 'infection' named entity 'H5N1' named entity 'Vietnam' named entity 'SARS-CoV' named entity 'class I MHC' named entity 'H3K4me3' named entity 'MHC' named entity 'tropism' named entity 'qPCR' named entity 'MERS-CoV' named entity 'antigen' named entity 'H5N1' named entity 'epigenetic modulation' named entity 'MDCK' named entity 'apoptosis' named entity 'MERS-CoV' named entity 'antigen presentation' named entity 'H1N1' named entity 'epigenetic mechanisms' named entity 'SARS-CoV' named entity 'epigenetic modifications' named entity 'transcription factors' named entity 'Pathogen' named entity 'protein' named entity 'adaptive immune response' named entity 'immune function' named entity 'type I IFN' named entity 'primer' named entity 'DNA methylation' named entity 'coronavirus' named entity 'down-regulation' named entity 'histone' named entity 'gene expression' named entity 'SARS-CoV' named entity 'down-regulation' named entity 'H5N1' named entity 'H1N1' named entity 'infection' named entity 'viruses' named entity 'MHC' named entity 'epigenetic mechanisms' named entity 'MERS-CoV' named entity 'methylation' named entity 'host-pathogen interaction' named entity 'CoV' named entity 'antigen' named entity 'H5N1' named entity 'H1N1' named entity 'ISGs' named entity 'DNA methylation' named entity 'proteomic' named entity 'H5N1'

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