About: lncRNA expression signatures in response to enterovirus 71 infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	lncRNA expression signatures in response to enterovirus 71 infection
Creator	Ke, Changwen Su, Juan Ma, Wenli Zheng, Wenling Guan, Dawei Amit, Guttman Bernstein, B Cabili, M Carey, B Cassady, J Chro, Fan, Qin Feldser, D French, C Garber, M Guttman, M Hacohen, N Huarte, M Jacks, T Jae-Nisch, R Kellis, M Khalil, A Lander, E Lin, M Mikkelsen, T Morales, D Presser, A Raj, A Regev, A Rinn, J Thomas, K Van Oudenaarden, A Yin, Zhixin Zuk, O
source	Elsevier; Medline; PMC
abstract	Abstract Outbreaks of hand, foot, and mouth disease caused by enterovirus 71 (EV71) have become considerable threats to the health of infants and young children. To identify the cellular long noncoding RNAs (lncRNAs) involved in the host response to EV71 infection, we performed comprehensive lncRNA and mRNA profiling in EV71-infected rhabdomyosarcoma cells through microarray. We observed the differential expression of more than 4800 lncRNAs during infection. Further analysis showed 160 regulated enhancer-like lncRNA and nearby mRNA pairs, as well as 313 regulated Rinn’s lncRNA [M. Guttman I. Amit, M. Garber, C. French, M.F. Lin, D. Feldser, M. Huarte, O. Zuk, B.W. Carey, J.P. Cassady, M.N. Cabili, R. Jaenisch, T.S. Mikkelsen, T. Jacks, N. Hacohen, B.E. Bernstein, M. Kellis, A. Regev, J.L. Rinn, E.S. Lander. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458 (2009) 223–227, A.M. Khalil, M. Guttman, M. Huarte, M. Garber, A. Raj, D. Rivea Morales, K. Thomas, A. Presser, B.E. Bernstein, A. van Oudenaarden, A. Regev, E.S. Lander, J.L. Rinn. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc. Natl. Acad. Sci. USA 106 (2009) 11667–11672] and nearby mRNA pairs. The results provided information for further research on the prevention and treatment of EV71 infection, as well as on distinguishing severe and mild EV71 cases.
has issue date	2013-01-11(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2012.11.101
bibo:pmid	23220233
has license	els-covid
sha1sum (hex)	822f91b5238e03eeeb14c3e15fa67d86f66b2e64
schema:url	https://doi.org/10.1016/j.bbrc.2012.11.101
resource representing a document's title	lncRNA expression signatures in response to enterovirus 71 infection
has PubMed Central identifier	PMC7092842
has PubMed identifier	23220233
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:822f91b5238e03eeeb14c3e15fa67d86f66b2e64#body_text
is schema:about of	named entity 'LNCRNA' named entity 'DISTINGUISHING' named entity 'USA' named entity 'ENHANCER' named entity 'MRNA' named entity 'LNCRNA' named entity '313' named entity 'NON-' named entity 'THREATS' named entity 'FOOT' named entity 'TO IDENTIFY' named entity '27S' named entity 'DIFFERENTIAL EXPRESSION' named entity 'CELLS' named entity 'RHABDOMYOSARCOMA' named entity 'MILD' named entity '4800' named entity 'LONG' named entity 'MAMMALS' named entity 'INTERGENIC' named entity 'INFECTED' named entity 'ACAD' named entity 'DISEASE CAUSED BY ENTEROVIRUS' named entity 'CELLULAR' named entity 'pairs' named entity 'rhabdomyosarcoma' named entity 'Nature' named entity 'ENTEROVIRUS 71 INFECTION' named entity 'OBSERVED' named entity 'HAND' named entity 'MORE THAN' named entity 'COMPREHENSIVE' named entity 'ASSOCIATE' named entity 'HEALTH' named entity 'INFORMATION' named entity 'MODIFYING' named entity 'EXPRESSION' named entity 'RESPONSE TO' named entity 'MICROARRAY' named entity 'NEARBY' named entity 'HIGHLY' named entity 'PERFORMED' named entity 'ANALYSIS' named entity 'RESULTS' named entity 'RESPONSE TO' named entity 'PAIRS' named entity 'COMPLEXES' named entity 'ENTEROVIRUS 71'

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