About: Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2
Creator	Linlin, Bao Liu, Ying Liu, Jiangning Qin, Chuan Xu, Yanfeng Gao, Hong Liu, Xing Xue, Jing Xiao, Chong Deng, Wei Yu, Pin Han, Yunlin Qu, Yajin Song, Zhiqi Zhao, Wenjie Gong, Shuran Li, Fengdi Liu, Jiayi Liu, Mingya Qi, Qi, Feifei Wang, Guanpeng Wang, Shunyi Xiang, Yu, Haisheng Zhao, Linna Zhiguang, Qiang,
Source	BioRxiv
abstract	A global pandemic of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is ongoing spread. It remains unclear whether the convalescing patients have a risk of reinfection. Rhesus macaques were rechallenged with SARS-CoV-2 during an early recovery phase from initial infection characterized by weight loss, interstitial pneumonia and systemic viral dissemination mainly in respiratory and gastrointestinal tracts. The monkeys rechallenged with the identical SARS-CoV-2 strain have failed to produce detectable viral dissemination, clinical manifestations and histopathological changes. A notably enhanced neutralizing antibody response might contribute the protection of rhesus macaques from the reinfection by SARS-CoV-2. Our results indicated that primary SARS-CoV-2 infection protects from subsequent reinfection. One Sentence Summary Neutralizing antibodies against SARS-CoV-2 might protect rhesus macaques which have undergone an initial infection from reinfection during early recovery days.
has issue date	2020-05-01(xsd:dateTime)
bibo:doi	10.1101/2020.03.13.990226
has license	biorxiv
sha1sum (hex)	8259ef2d0a7bcba91453c0adf969ae5b3c11916a
schema:url	https://doi.org/10.1101/2020.03.13.990226
resource representing a document's title	Lack of Reinfection in Rhesus Macaques Infected with SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:8259ef2d0a7bcba91453c0adf969ae5b3c11916a#body_text
is schema:about of	named entity 'COVID-19' named entity 'viral RNA' named entity 'histopathological' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'rhesus macaques' named entity 'rhesus macaques' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'Rhesus Macaques' named entity 'pneumonia' named entity 'primary infection' named entity 'antibodies' named entity 'Rechallenge' named entity 'SARS-CoV-2' named entity 'neutralizing antibodies' named entity 'primary infection' named entity 'GraphPad Prism' named entity 'antibodies' named entity 'SARS-CoV-2' named entity 'p<0.01' named entity 'two-tailed' named entity 'mucosal immunity' named entity 'neutralizing antibodies' named entity 'statistical significance' named entity 'Welch's t-test' named entity 'SARS-CoV-2' named entity 'X-ray' named entity 'antibodies' named entity 'necropsy' named entity 'monocytes' named entity 'time window' named entity 'primary infection' named entity 'nonhuman primates' named entity 'Neutralizing antibody' named entity 'CD4 +' named entity 'antibody response' named entity 'SARS-CoV-2' named entity 'Short Title' named entity 'infection' named entity 'SARS-CoV-2' named entity 'global pandemic' named entity 'initial infection' named entity 'SARS-CoV-2' named entity 'Neutralizing antibodies' named entity 'rechallenged' named entity 'Corona Virus Disease 2019' named entity 'weight loss' named entity 'systemic viral' named entity 'initial infection' named entity 'infection' covid:arg/8259ef2d0a7bcba91453c0adf969ae5b3c11916a named entity 'interstitial pneumonia' named entity 'rechallenged' named entity 'gastrointestinal tracts' named entity 'COVID' named entity 'Rhesus macaques'

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