About: IL‐1 blockade with anakinra in acute leukaemia patients with severe COVID‐19 pneumonia appears safe and may result in clinical improvement

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About: IL‐1 blockade with anakinra in acute leukaemia patients with severe COVID‐19 pneumonia appears safe and may result in clinical improvement Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IL‐1 blockade with anakinra in acute leukaemia patients with severe COVID‐19 pneumonia appears safe and may result in clinical improvement
Creator	Halsey, Richard Carpenter, Ben Day, James Fox, Thomas Kottaridis, Panagiotis
topic	covid:825b5dc4c469ec27707425cc20609099a0b152fc#this
Source	Medline; PMC
abstract	As of 17th May, 2020 the number of patients infected by coronavirus disease 2019 (COVID‐19) worldwide has exceeded 4.5 million (WHO 2020). A subgroup of patients with COVID‐19 pneumonia develop a hyperinflammatory syndrome which has a similar cytokine release profile to secondary haemophagocytic lymphohistiocytosis (HLH) (Huang, et al 2020). Immunomodulatory drugs are hypothesised to abrogate the dysfunctional immune response in hyperinflammatory COVID‐19 and are currently being investigated in clinical trials. IL‐1 blockage with anakinra has been shown to be safe and is associated with clinical improvement in patients with hyperinflammatory COVID‐19 (Cavalli, et al 2020).
has issue date	2020-05-21(xsd:dateTime)
bibo:doi	10.1111/bjh.16873
bibo:pmid	32438450
has license	no-cc
sha1sum (hex)	825b5dc4c469ec27707425cc20609099a0b152fc
schema:url	https://doi.org/10.1111/bjh.16873
resource representing a document's title	IL‐1 blockade with anakinra in acute leukaemia patients with severe COVID‐19 pneumonia appears safe and may result in clinical improvement
has PubMed Central identifier	PMC7280623
has PubMed identifier	32438450
schema:publication	Br J Haematol
resource representing a document's body	covid:825b5dc4c469ec27707425cc20609099a0b152fc#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/825b5dc4c469ec27707425cc20609099a0b152fc
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