About: Heparan Sulfate Proteoglycans in Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Heparan Sulfate Proteoglycans in Infection
Creator	Park, P Bartlett, A Bartlett, Allison Park, Pyong
Source	PMC
abstract	To cause infections, microbial pathogens elaborate a multitude of factors that interact with host components. Using these host–pathogen interactions to their advantage, pathogens attach, invade, disseminate, and evade host defense mechanisms to promote their survival in the hostile host environment. Many viruses, bacteria, and parasites express adhesins that bind to cell surface heparan sulfate proteoglycans (HSPGs) to facilitate their initial attachment and subsequent cellular entry. Some pathogens also secrete virulence factors that modify HSPG expression. HSPGs are ubiquitously expressed on the cell surface of adherent cells and in the extracellular matrix. HSPGs are composed of one or several heparan sulfate (HS) glycosaminoglycan chains attached covalently to specific core proteins. For most intracellular pathogens, cell surface HSPGs serve as a scaffold that facilitates the interaction of microbes with secondary receptors that mediate host cell entry. Consistent with this mechanism, addition of HS or its pharmaceutical functional mimic, heparin, inhibits microbial attachment and entry into cultured host cells, and HS-binding pathogens can no longer attach or enter cultured host cells whose HS expression has been reduced by enzymatic treatment or chemical mutagenesis. In pathogens where the specific HS adhesin has been identified, mutant strains lacking HS adhesins are viable and show normal growth rates, suggesting that the capacity to interact with HSPGs is strictly a virulence activity. The goal of this chapter is to provide a mechanistic overview of our current understanding of how certain microbial pathogens subvert HSPGs to promote their infection, using specific HSPG–pathogen interactions as representative examples.
has issue date	2011-03-19(xsd:dateTime)
bibo:doi	10.1007/978-3-642-16833-8_2
has license	no-cc
sha1sum (hex)	8265802ea1d7844ea39c53f73e51dc3213440533
schema:url	https://doi.org/10.1007/978-3-642-16833-8_2
resource representing a document's title	Heparan Sulfate Proteoglycans in Infection
has PubMed Central identifier	PMC7120983
schema:publication	Glycans in Diseases and Therapeutics
resource representing a document's body	covid:8265802ea1d7844ea39c53f73e51dc3213440533#body_text
is schema:about of	named entity 'facilitates' named entity 'provide' named entity 'adhesins' named entity 'host' named entity 'inhibits' named entity 'initial' named entity 'pathogens' named entity 'virulence factors' named entity 'GLYCOSAMINOGLYCAN' named entity 'MODIFY' named entity 'CHEMICAL MUTAGENESIS' named entity 'ATTACH' named entity 'CONSISTENT WITH' named entity 'THE CELL' named entity 'VIABLE' named entity 'LACKING' named entity 'HEPARAN SULFATE PROTEOGLYCANS' named entity 'GROWTH RATES' named entity 'SECONDARY' named entity 'SCAFFOLD' named entity 'CELL SURFACE' named entity 'ITS' named entity 'VIRUSES' named entity 'INTERACTIONS' named entity 'INTERACTION' named entity 'COMPOSED OF' named entity 'WHERE' named entity 'EXPRESSED' named entity 'NORMAL GROWTH' named entity 'PATHOGENS' named entity 'THESE' named entity 'PROTEINS' named entity 'SPECIFIC' named entity 'CELLULAR' named entity 'REDUCED' named entity 'CHAINS' named entity 'HS-' named entity 'ADHERENT' named entity 'HSPG' named entity 'HOW' named entity 'SUBSEQUENT' named entity 'PARASITES' named entity 'HEPARAN SULFATE PROTEOGLYCANS' named entity 'VIRULENCE FACTORS' named entity 'DISSEMINATE' named entity 'HOST-PATHOGEN INTERACTIONS' named entity 'GOAL' named entity 'DEFENSE MECHANISMS' named entity 'OVERVIEW' named entity 'BIND' named entity 'HOST DEFENSE' named entity 'ADHESIN' named entity 'ADVANTAGE' named entity 'ACTIVITY' named entity 'CERTAIN' named entity 'MIMIC' named entity 'TREATMENT' named entity 'ENVIRONMENT' named entity 'BINDING' named entity 'MICROBES' named entity 'HEPARIN' named entity 'INFECTION' named entity 'UNDERSTANDING' named entity 'EXPRESS' named entity 'EXTRACELLULAR MATRIX' named entity 'CHAPTER' named entity 'VIRULENCE' named entity 'COMPONENTS' named entity 'HOST CELLS' named entity 'CULTURED' named entity 'MUTANT STRAINS' named entity 'FUNCTIONAL' named entity 'HOSTILE' named entity 'ELABORATE' named entity 'ENTER' named entity 'OUR' named entity 'CAPACITY' named entity 'CORE' named entity 'ENZYMATIC' named entity 'SURVIVAL'

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