About: The minimalist architectures of viroporins and their therapeutic implications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The minimalist architectures of viroporins and their therapeutic implications
Creator	Chou, James Ouyang, Bo
Source	Elsevier; Medline; PMC
abstract	Abstract Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named viroporins, are crucial for viral pathogenicity. In the past five years, structures obtained by nuclear magnetic resonance (NMR), X-ray crystallography, and electron microscopy (EM) showed that viroporins often adopt minimalist architectures to achieve their functions. A number of small molecules have been identified to interfere with their channel activities and thereby inhibit viral infection, making viroporins potential drug targets for therapeutic intervention. The known architectures and inhibition mechanisms of viroporins differ significantly from each other, but some common principles are shared between them. This review article summarizes the recent developments in the structural investigation of viroporins and their inhibition by antiviral compounds. This article is part of a Special Issue entitled: Viral Membrane Proteins—Channels for Cellular Networking.
has issue date	2014-04-30(xsd:dateTime)
bibo:doi	10.1016/j.bbamem.2013.09.004
bibo:pmid	24055819
has license	els-covid
sha1sum (hex)	828eb6735d0f1b3883d174d12134a4dfcb9af1eb
schema:url	https://doi.org/10.1016/j.bbamem.2013.09.004
resource representing a document's title	The minimalist architectures of viroporins and their therapeutic implications
has PubMed Central identifier	PMC3943691
has PubMed identifier	24055819
schema:publication	Biochimica et Biophysica Acta (BBA) - Biomembranes
resource representing a document's body	covid:828eb6735d0f1b3883d174d12134a4dfcb9af1eb#body_text
is schema:about of	named entity 'KNOWN' named entity 'VIRAL MEMBRANE' named entity 'INVESTIGATION' named entity 'ELECTRON MICROSCOPY' named entity 'INHIBITION' named entity 'BUT' named entity 'RECENT' named entity 'SPECIAL' named entity 'CATIONS' named entity 'FORM' named entity 'AID' named entity 'DRUG TARGETS' named entity 'INTERFERE' named entity 'FUNCTIONS' named entity 'NUCLEAR MAGNETIC RESONANCE' named entity 'STRUCTURES' named entity 'POTENTIAL' named entity 'REVIEW' named entity 'HAVE' named entity 'MECHANISMS' named entity 'VARIOUS' named entity 'CHANNEL' named entity 'THEIR' named entity 'COMMON' named entity 'OBTAINED BY' named entity 'STRUCTURAL' named entity 'ANTIVIRAL' named entity 'MEMBRANE' named entity 'INTEGRAL MEMBRANE PROTEINS' named entity 'PART OF' named entity 'GENOMES' named entity 'MEMBRANE PROTEINS' named entity 'ARTICLE' named entity 'SHARED' named entity 'ENCODE' named entity 'CHANNELS' named entity 'VIRAL PROTEINS' named entity 'MOLECULES' named entity 'VIRAL ENTRY' named entity 'THERAPEUTIC INTERVENTION' named entity 'NAMED' named entity 'X-RAY CRYSTALLOGRAPHY' named entity 'NETWORKING' named entity 'MATURATION' named entity 'THEIR' named entity 'THERAPEUTIC' named entity 'ADOPT' named entity 'THESE' named entity 'IDENTIFIED' named entity 'SMALL' named entity 'CELLULAR' named entity 'NUMBER OF' named entity 'VIRAL INFECTION' named entity 'STEPS' named entity 'IN THE PAST' named entity 'ACROSS' named entity 'PROTONS' named entity 'ACTIVITIES' named entity 'YEARS' named entity 'HOMO' named entity 'SMALL MOLECULES' named entity 'TRANSPORT' named entity 'DEVELOPMENTS' named entity 'ISSUE' named entity 'BARRIER' named entity 'PATHOGENICITY' named entity 'VIRAL' named entity 'viral infection' named entity 'protons' named entity 'mechanisms' named entity 'compounds' named entity 'steps' named entity 'channels' named entity 'inhibit' named entity 'small molecules' named entity 'barrier' named entity 'X-ray crystallography' named entity 'number' named entity 'implications' named entity 'viral proteins'

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