About: Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients

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About: Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients
Creator	Izopet, Jacques Mansuy, Jean-Michel Abravanel, Florence Dubois, Martine Kamar, Nassim Garrouste, Cyril Lhomme, Sebastien Rostaing, Lionel Saune, Karine
Source	Medline; PMC
abstract	Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 and the outcome of infection in solid-organ transplant patients. Both sequence entropy and genetic distances during the hepatitis E acute phase were higher in patients whose infection became chronic than in those who cleared the virus. Hence, great quasispecies heterogeneity in the regions encoding the PPR and the macro domain may facilitate HEV persistence.
has issue date	2014-01-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jit438
bibo:pmid	23964111
has license	no-cc
sha1sum (hex)	82ad77b161e31fb733c63e3ebe5067c938d43d40
schema:url	https://doi.org/10.1093/infdis/jit438
resource representing a document's title	Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients
has PubMed Central identifier	PMC7107305
has PubMed identifier	23964111
schema:publication	J Infect Dis
resource representing a document's body	covid:82ad77b161e31fb733c63e3ebe5067c938d43d40#body_text
is schema:about of	named entity 'IMMUNOCOMPROMISED PATIENTS' named entity 'HEV' named entity 'virus' named entity 'patients' named entity 'domain' named entity 'domain' named entity 'Genetic' named entity 'INFLUENCE' named entity 'POLYPROLINE' named entity 'HEPATITIS E VIRUS' named entity 'PROTEIN ' named entity 'VIRUS' named entity 'HETEROGENEITY' named entity 'IMMUNOCOMPROMISED PATIENTS' named entity 'DOMAIN' named entity 'HOST IMMUNE RESPONSE' named entity 'POLYPROLINE' named entity 'OUTCOME' named entity 'GENETIC HETEROGENEITY' named entity 'HEV' named entity 'INVESTIGATED' named entity 'MACRO' named entity 'DOMAIN' named entity 'PERSISTENCE' named entity 'REGION' named entity 'HEV' named entity 'GENETIC HETEROGENEITY' named entity 'ORF1' named entity 'ACUTE PHASE' named entity 'SEQUENCE' named entity 'ASSOCIATION' named entity 'CHRONIC' named entity 'SOLIDORGAN' named entity 'MACRO' named entity 'PERSISTENCE' named entity 'GENETIC' named entity 'GREAT' named entity 'ENTROPY' named entity 'MODULATE' named entity 'TRANSPLANT' named entity 'HIGHER' named entity 'PPR' named entity 'REGION' named entity 'INFECTION' named entity 'DISTANCES' named entity 'VIRUS PRODUCTION' named entity 'CLEARED' named entity 'CHRONICALLY' named entity 'QUASISPECIES' named entity 'ENCODING' named entity 'INFECT' named entity 'PATIENTS' named entity 'HEPATITIS E' covid:arg/82ad77b161e31fb733c63e3ebe5067c938d43d40 named entity 'ORF1' named entity 'HEV' named entity 'great' named entity 'HEV' named entity 'chronically' named entity 'hepatitis' named entity 'genetic heterogeneity' named entity 'HEV' named entity 'genotype' named entity 'pathogenicity' named entity 'Homologies' named entity 'organ transplant' named entity 'virus' named entity 'infection' named entity 'France' named entity 'RNA' named entity 'quasispecies' named entity 'RNA' named entity 'zoonotic disease'

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