About: Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China

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About: Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China
Creator	Li, Xiao Xu, Duo Zhou, Rong Zeng, Zhi-Qi Chen, De-Hui Liang, Huan-Xi Liu, Wen-Kuan Tan, Wei-Ping Chen, Mei-Xin Lin, Zheng-Shi Qiu, Shu-Yan
Source	Medline; PMC
abstract	Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to June 2016 in Guangzhou, China. These were tested for four strains of HCoV infection using real-time polymerase chain reaction (PCR). HCoV-positive patients were then tested for 11 other respiratory pathogens. 4.3% (489/11399) of patients were positive for HCoV, of which 3.0% were positive for OC43 (346/11399), 0.6% for 229E (65/11399), 0.5% for NL63 (60/11399), and 0.3% for HKU1 (38/11399). Patients aged 7–12 months had the highest prevalence of HCoV and OC43 when compared with other age groups (p < 0.001). The peak seasons of infection varied depending on the HCoV strain. Patients infected with a single strain of HCoV infection were less likely to present fever (≥ 38 °C) (p = 0.014) and more likely to present pulmonary rales (p = 0.043) than those co-infected with more than one HCoV strain or other respiratory pathogens. There were also significant differences in the prevalence of certain symptoms, including coughing (p = 0.032), pneumonia (p = 0.026), and abnormal pulmonary rales (p = 0.002) according to the strain of HCoV detected. This retrospective study of the prevalence of four HCoV strains and clinical signs among a large population of pediatric patients in a subtropical region of China provides further insight into the epidemiology and clinical features of HCoV.
has issue date	2017-12-06(xsd:dateTime)
bibo:doi	10.1007/s10096-017-3144-z
bibo:pmid	29214503
has license	cc-by
sha1sum (hex)	82c17f8de937704b2522db77b863f8f01ab19414
schema:url	https://doi.org/10.1007/s10096-017-3144-z
resource representing a document's title	Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China
has PubMed Central identifier	PMC5780525
has PubMed identifier	29214503
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:82c17f8de937704b2522db77b863f8f01ab19414#body_text
is schema:about of	named entity 'CHINA' named entity 'chain reaction' named entity 'symptoms' named entity 'tested' named entity 'hospitalized' named entity 'respiratory tract' named entity '229E' named entity '28P' named entity 'THROAT' named entity 'OC43' named entity 'CORONAVIRUSES' named entity 'REAL-TIME POLYMERASE CHAIN REACTION' named entity 'RETROSPECTIVE STUDY' named entity 'CLINICAL CHARACTERISTICS' named entity 'CLINICAL FEATURES' named entity 'RESPIRATORY DISEASES' named entity 'POSITIVE' named entity 'COUGHING' named entity 'ABNORMAL' named entity 'PULMONARY RALES' named entity 'HIGHEST' named entity 'WORLDWIDE' named entity 'PNEUMONIA' named entity 'SYMPTOMS' named entity 'VARIOUS' named entity 'LARGE' named entity 'COMMON' named entity 'TESTED FOR' named entity 'PRESENT' named entity 'SWABS' named entity 'MORE THAN ONE' named entity 'NL63' named entity 'THESE' named entity 'ACUTE RESPIRATORY TRACT INFECTION' named entity 'EPIDEMIOLOGY' named entity '0.3' named entity '0.5' named entity 'CORONAVIRUSES' named entity 'EPIDEMIOLOGY' named entity 'HUMAN' named entity 'STUDY' named entity 'HOSPITALIZED CHILDREN' named entity 'CERTAIN' named entity 'ACCORDING' named entity '032' named entity '28489' named entity 'PEDIATRIC' named entity '28346' named entity 'THE PEAK' named entity '0.001' named entity 'SEASONS' named entity 'PATIENTS' named entity 'CAUSE' named entity 'AGE GROUPS' named entity 'INFECTION' named entity '2860' named entity 'COMPARED' named entity 'USING' named entity 'STRAIN' named entity 'RESPIRATORY VIRUSES' named entity 'HOSPITALIZED CHILDREN' named entity 'OF EVIDENCE' named entity '12 MONTHS' named entity 'POPULATION' named entity 'IS A' named entity 'FEVER' named entity 'SUBTROPICAL' named entity 'DETECTED' named entity 'REGION' named entity 'NL63' named entity 'COLLECTED'

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