About: Gene–disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections

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About: Gene–disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gene–disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections
Creator	Chinnaswamy, S
Source	Medline; PMC
abstract	Interferon (IFN) lambda (IFN-λ or type III IFN) gene polymorphisms were discovered in the year 2009 to have a strong association with spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection in human hosts. This landmark discovery also brought renewed interest in type III IFN biology. After more than half a decade since this discovery, we now have reports that show that genetic association of IFNL gene polymorphisms in humans is not limited only to HCV infections but extends beyond, to include varied diseases such as non-alcoholic fatty liver disease, allergy and several other viral diseases including that caused by the human immunodeficiency virus. Notably, all these conditions have strong involvement of host innate immune responses. After the discovery of a deletion polymorphism that leads to the expression of a functional IFN-λ4 as the prime ‘functional’ variant, the relevance of other polymorphisms regulating the expression of IFN-λ3 is in doubt. Herein, I seek to critically address these issues and review the current literature to provide a framework to help further understanding of IFN-λ biology. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/gene.2016.24) contains supplementary material, which is available to authorized users.
has issue date	2016-06-09(xsd:dateTime)
bibo:doi	10.1038/gene.2016.24
bibo:pmid	27278127
has license	no-cc
sha1sum (hex)	82cec9273215e27cc141926b184323b77f8f01fc
schema:url	https://doi.org/10.1038/gene.2016.24
resource representing a document's title	Gene–disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections
has PubMed Central identifier	PMC7091887
has PubMed identifier	27278127
schema:publication	Genes Immun
resource representing a document's body	covid:82cec9273215e27cc141926b184323b77f8f01fc#body_text
is schema:about of	named entity 'caused' named entity 'deletion' named entity 'GENETIC ASSOCIATION' named entity 'HEPATITIS C VIRUS' named entity 'LEADS' named entity 'BROUGHT' named entity 'DOUBT' named entity 'ASSOCIATION' named entity 'YEAR' named entity 'ADDRESS' named entity 'HUMANS' named entity '2009' named entity 'After' named entity 'functional' named entity 'This' named entity 'discovery' named entity 'lambda' named entity 'humans' named entity 'functional' named entity 'prime' named entity 'renewed' named entity 'conditions' named entity 'IFN-λ' named entity 'regulating the expression' named entity 'type III' named entity 'Interferon' named entity 'gene' named entity 'innate immune responses' named entity 'viral diseases' named entity 'alleles' named entity 'messenger RNA' named entity 'innate immune response' named entity 'herpes simplex virus' named entity 'intron' named entity 'prophylaxis' named entity 'IFNL' named entity 'serum' named entity 'Th1' named entity 'allele' named entity 'adaptive immunity' named entity 'genotype' named entity 'HIV' named entity 'molecular mechanism' named entity 'janus kinase' named entity 'allele' named entity 'allergy' named entity 'HIV' named entity 'asymptomatic carriers' named entity 'alleles' named entity 'signal transduction' named entity 'phenotype' named entity 'recessive' named entity 'HBV' named entity 'allele' named entity 'CMV' named entity 'SNP' named entity 'HCV' named entity 'Han Chinese' named entity 'IFNL' named entity 'NF-κB' named entity 'HCV' named entity 'National Center for Biotechnology Information' named entity 'cytokines' named entity 'IFNL' named entity 'ISG' named entity 'RNA-sequencing' named entity 'allele' named entity 'cell types' named entity 'IFNL4' named entity 'adult T-cell leukemia/lymphoma' named entity 'IFN-α' named entity 'monocyte-derived dendritic cells' named entity 'receptor' named entity 'HCV' named entity 'HCV' named entity 'innate immunity' named entity 'inflammation' named entity 'HCV' named entity 'HBV' named entity 'IFN' named entity 'IFN'

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