About: Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin

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About: Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin
Creator	Kageyama, Tsutomu Suzuki, Tadaki Nakajima, Noriko Furuya, Hiroyuki Kawachi, Shoji Nunoi, Hiroyuki Bich, Thuy Dao, Huu Dien, \| Do Msc, Thu Hai, \| Huong, \| Le, Thanh Nam, \| Phan, Huu Phd, Phung Phuc, \| Ta, Anh Tran, Minh Tuan, \|
source	Medline; PMC
abstract	BACKGROUND: Acute respiratory distress syndrome (ARDS) is one of the most lethal diseases encountered in the pediatric intensive care unit (PICU). The etiological pathogens and prognostic factors of severe ARDS of pulmonary origin in children with respiratory virus infections were prospectively investigated. METHODS: Enrolled children fulfilled the following criteria: (1) PICU admission; (2) age of 1 month to 16 years; (3) diagnosis of infectious pneumonia and respiratory virus infection; and (4) development of severe ARDS within 72 h after PICU admission. Pathogens were detected in the blood and tracheal lavage fluid using molecular techniques and a conventional culture system. The serum levels of inflammatory mediators on the day of PICU admission were examined. RESULTS: Fifty‐seven patients (32 boys; median age, 9 months) were enrolled. Multiple virus infections, co‐infection with bacteria/fungus, and bacteremia/fungemia were observed in 60%, 49%, and 32% of children, respectively. Adenovirus‐B, measles virus, and cytomegalovirus were detected predominantly in tracheal lavage fluid. There were no statistically significant differences between non‐survivors and survivors regarding the types of pathogen, incidence of multiple virus infection, gender, age, clinical features, and treatment. The serum levels of interferon (IFN)‐γ and the IFN‐γ/interleukin (IL)‐10 ratio were higher in non‐survivors. CONCLUSIONS: IFN‐γ upregulation as detected on the day of PICU admission was found to be one of the possible prognostic factors affecting a fatal outcome. These results suggest that modulation of inflammatory responses is critical for the clinical management of children with ARDS.
has issue date	2017-07-13(xsd:dateTime)
bibo:doi	10.1002/ppul.23694
bibo:pmid	28703486
has license	cc-by-nc
sha1sum (hex)	82dcb53e236df1adb5c3c9f5291dc4e8eabb354a
schema:url	https://doi.org/10.1002/ppul.23694
resource representing a document's title	Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin
has PubMed Central identifier	PMC5697698
has PubMed identifier	28703486
schema:publication	Pediatr Pulmonol
resource representing a document's body	covid:82dcb53e236df1adb5c3c9f5291dc4e8eabb354a#body_text
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