About: Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury
Creator	Zhang, Yue He, Tian Zhang, Z Lu, X Wang, C Shao, Y Lu, Tao Qin, Caimeng Qin, R Qu, Rendong Qu, T Shao, Xiangming Wang, Zheyi
source	Elsevier; Medline; PMC
abstract	Clinical studies have shown that renal injury in Corona Virus Disease 2019 (COVID-19) patients has been a real concern, which is associated with high mortality and an inflammation/apoptosis-related causality. Effective target therapy for renal injury has yet been developed. Besides, potential anti-COVID-19 medicines have also been reported to cause adverse side effects to kidney. Chinese Herbal Medicine (CHM), however, has rich experience in treating renal injury and has successfully applied in China in the battle of COVID-19. Nevertheless, the molecular mechanisms of CHM treatment are still unclear. In this study, we searched prescriptions in the treatment of renal injury extensively and the potential mechanisms to treat COVID-19 related renal injury were investigated. The association rules analysis showed that the core herbs includes Huang Qi, Fu Ling, Bai Zhu, Di Huang, Shan Yao. TCM herbs regulate core pathways, such as AGE-RAGE, PI3K-AKT, TNF and apoptosis pathway, etc. The ingredients (quercetin, formononetin, kaempferol, etc.,) from core herbs could modulate targets (PTGS2 (COX2), PTGS1 (COX1), IL6, CASP3, NOS2, and TNF, etc.), and thereby prevent the pharmacological and non-pharmacological renal injury comparable to that from COVID-19 infection. This study provides therapeutic potentials of CHM to combat COVID-19 related renal injury to reduce complications and mortality.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1016/j.jsps.2020.08.002
bibo:pmid	32837217
has license	no-cc
sha1sum (hex)	83085aa010b912f6f06474a8a9c7c6fbda4ee7df
schema:url	https://doi.org/10.1016/j.jsps.2020.08.002
resource representing a document's title	Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury
has PubMed Central identifier	PMC7416081
has PubMed identifier	32837217
schema:publication	Saudi Pharm J
resource representing a document's body	covid:83085aa010b912f6f06474a8a9c7c6fbda4ee7df#body_text
is schema:about of	named entity 'COVID' named entity 'Chinese Herbal Medicine' named entity 'pneumonia' named entity 'lipid metabolism' named entity 'CHM' named entity 'kidney diseases' named entity 'anti-apoptotic' named entity 'PGE2' named entity 'Fu Ling' named entity 'IL17' named entity 'oxidative stress' named entity 'critically ill' named entity 'TGF-β' named entity 'immune function' named entity 'renal injury' named entity 'renal injury' named entity 'modern medicine' named entity 'Chinese Herbal Medicine' named entity 'renal injury' named entity 'Beijing' named entity 'IL6' named entity 'COVID-19' named entity 'ACE2' named entity 'prognostic factor' named entity 'pharmacological' named entity 'CHM' named entity 'pharmacological' named entity 'antibacterial drugs' named entity 'adverse effects' named entity 'inflammation' named entity 'renal injury' named entity 'acetaminophen' named entity 'COVID-19 infection' named entity 'decoction' named entity 'covid-19' named entity 'triterpenoids' named entity 'Huang Qi' named entity 'clinical practice' named entity 'COX1' named entity 'MAPK pathway' named entity 'COVID-19' named entity 'statistical analysis' named entity 'COX2' named entity 'Uniport' named entity 'CHM' named entity 'signaling pathways' named entity 'PI3K-Akt' named entity 'active ingredients' named entity 'renal injury' named entity 'drug-induced' named entity 'inflammation' named entity 'kaempferol' named entity 'COVID-19' named entity 'SARS' named entity 'immunogenic' named entity 'ACE2' named entity 'renal injury' named entity 'fibrosis' named entity 'epithelial cells' named entity 'COVID-19' named entity 'COVID-19' named entity 'PTGS2' named entity 'renal injury' named entity 'PI3K/Akt' named entity 'renal injury' named entity 'Homo sapiens' named entity 'MERS' named entity 'immune regulation' named entity 'apoptosis'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software